CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition

Two out of 41 non-small cell lung cancer patients enrolled in a clinical study were found with a somatic CRAF mutation in their tumor, namely CRAF(P261A) and CRAF(P207S). To our knowledge, both mutations are novel in lung cancer and CRAF(P261A) has not been previously reported in cancer. Expression...

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Detalles Bibliográficos
Autores principales: Noeparast, Amir, Giron, Philippe, Noor, Alfiah, Bahadur Shahi, Rajendra, De Brakeleer, Sylvia, Eggermont, Carolien, Vandenplas, Hugo, Boeckx, Bram, Lambrechts, Diether, De Grève, Jacques, Teugels, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756226/
https://www.ncbi.nlm.nih.gov/pubmed/31285551
http://dx.doi.org/10.1038/s41388-019-0866-7

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