Nerve growth factor–mediated photoablation of nociceptors reduces pain behavior in mice

Nerve growth factor (NGF) and its receptors TrkA and p75 play a key role in the development and function of peripheral nociceptive neurons. Here, we describe novel technology to selectively photoablate TrkA-positive nociceptors through delivery of a phototoxic agent coupled to an engineered NGF liga...

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Detalles Bibliográficos
Autores principales: Nocchi, Linda, Portulano, Carla, Franciosa, Federica, Doleschall, Balint, Panea, Mirela, Roy, Nainika, Maffei, Mariano, Gargano, Alessandra, Perlas, Emerald, Heppenstall, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756257/
https://www.ncbi.nlm.nih.gov/pubmed/31365468
http://dx.doi.org/10.1097/j.pain.0000000000001620

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