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AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review
Hepatoid adenocarcinoma (HAC) is a group of neoplasms with features resembling hepatocellular carcinoma. The stomach is the most commonly affected organ among the reported primary sites. We report the case of a 28-year-old man with chronic hepatitis B and a complaint of abdominal distension. The pat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756369/ https://www.ncbi.nlm.nih.gov/pubmed/31571915 http://dx.doi.org/10.2147/OTT.S216501 |
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author | Zou, Man Li, Yanhui Dai, Yuhong Sun, Li Huang, Tingting Yuan, Xianglin Qiu, Hong |
author_facet | Zou, Man Li, Yanhui Dai, Yuhong Sun, Li Huang, Tingting Yuan, Xianglin Qiu, Hong |
author_sort | Zou, Man |
collection | PubMed |
description | Hepatoid adenocarcinoma (HAC) is a group of neoplasms with features resembling hepatocellular carcinoma. The stomach is the most commonly affected organ among the reported primary sites. We report the case of a 28-year-old man with chronic hepatitis B and a complaint of abdominal distension. The patient was examined by PET-CT and magnetic resonance imaging (MRI), which showed diffuse thickening of the peritoneum and omentum but no mass was found in the liver. Pathological examination of a biopsy of the omental nodules was consistent with moderately differentiated hepatocellular carcinoma (HCC); thus, a diagnosis of HAC of the peritoneum and omentum was established. The patient received a chemotherapy regimen consisting of oxaliplatin and capecitabine and gained remarkable effects as the AFP level dropped significantly, and the tumour nearly disappeared. When the patient shifted to the standard multikinase inhibitors, Sorafenib or Lenvatinib, both treatments were ineffective. HAC is a heterogeneous group of prognostically unfavourable tumours mimicking the histological appearance of HCC, and the treatment outcomes are still unclear. |
format | Online Article Text |
id | pubmed-6756369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-67563692019-09-30 AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review Zou, Man Li, Yanhui Dai, Yuhong Sun, Li Huang, Tingting Yuan, Xianglin Qiu, Hong Onco Targets Ther Case Report Hepatoid adenocarcinoma (HAC) is a group of neoplasms with features resembling hepatocellular carcinoma. The stomach is the most commonly affected organ among the reported primary sites. We report the case of a 28-year-old man with chronic hepatitis B and a complaint of abdominal distension. The patient was examined by PET-CT and magnetic resonance imaging (MRI), which showed diffuse thickening of the peritoneum and omentum but no mass was found in the liver. Pathological examination of a biopsy of the omental nodules was consistent with moderately differentiated hepatocellular carcinoma (HCC); thus, a diagnosis of HAC of the peritoneum and omentum was established. The patient received a chemotherapy regimen consisting of oxaliplatin and capecitabine and gained remarkable effects as the AFP level dropped significantly, and the tumour nearly disappeared. When the patient shifted to the standard multikinase inhibitors, Sorafenib or Lenvatinib, both treatments were ineffective. HAC is a heterogeneous group of prognostically unfavourable tumours mimicking the histological appearance of HCC, and the treatment outcomes are still unclear. Dove 2019-09-18 /pmc/articles/PMC6756369/ /pubmed/31571915 http://dx.doi.org/10.2147/OTT.S216501 Text en © 2019 Zou et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Report Zou, Man Li, Yanhui Dai, Yuhong Sun, Li Huang, Tingting Yuan, Xianglin Qiu, Hong AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review |
title | AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review |
title_full | AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review |
title_fullStr | AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review |
title_full_unstemmed | AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review |
title_short | AFP-producing hepatoid adenocarcinoma (HAC) of peritoneum and omentum: a case report and literature review |
title_sort | afp-producing hepatoid adenocarcinoma (hac) of peritoneum and omentum: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756369/ https://www.ncbi.nlm.nih.gov/pubmed/31571915 http://dx.doi.org/10.2147/OTT.S216501 |
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