A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition

Integrating single-cell trajectory analysis with pooled genetic screening could reveal the genetic architecture that guides cellular decisions in development and disease. We applied this paradigm to probe the genetic circuitry that controls epithelial-to-mesenchymal transition (EMT). We profiled epi...

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Detalles Bibliográficos
Autores principales: McFaline-Figueroa, José L., Hill, Andrew J., Qiu, Xiaojie, Jackson, Dana, Shendure, Jay, Trapnell, Cole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756480/
https://www.ncbi.nlm.nih.gov/pubmed/31477929
http://dx.doi.org/10.1038/s41588-019-0489-5

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