Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

[Image: see text] CK2α and CK2α′ are the two isoforms of the catalytic subunit of human protein kinase CK2, an important target for cancer therapy. They have similar, albeit not identical functional and structural properties, and were occasionally reported to be inhibited with distinct efficacies by...

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Detalles Bibliográficos
Autores principales: Lindenblatt, Dirk, Nickelsen, Anna, Applegate, Violetta M., Hochscherf, Jennifer, Witulski, Benedict, Bouaziz, Zouhair, Marminon, Christelle, Bretner, Maria, Le Borgne, Marc, Jose, Joachim, Niefind, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756786/
https://www.ncbi.nlm.nih.gov/pubmed/31559376
http://dx.doi.org/10.1021/acsomega.8b03415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756786/
https://www.ncbi.nlm.nih.gov/pubmed/31559376
http://dx.doi.org/10.1021/acsomega.8b03415

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