Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées

INTRODUCTION: hepatitis C virus (HCV) has several extra-hepatic manifestations including cryoglubulinemia. Cryoglobulinemia is defined as the abnormal presence in the blood of one or several proteins (cryoglobulins) that can precipitate at low temperatures. METHOD: We conducted a cross-sectional ana...

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Autores principales: Eloumou, Servais Albert Fiacre Bagnaka, Mefo'o, Jean Pierre Nda, Nga, Winnie Tatiana Bekolo, Kenfack, Gabin Ulrich, Yakana, Linus, Malongue, Agnès, Okalla, Cecile, Kowo, Mathurin, Andoulo, Firmin Ankoune, Tzeuton, Christian, Bidja, Marie Solange Doualla, Namme, Henry Luma, Adiogo, Dieudonne, Noah, Dominique Noah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756798/
https://www.ncbi.nlm.nih.gov/pubmed/31565130
http://dx.doi.org/10.11604/pamj.2019.33.169.19162
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author Eloumou, Servais Albert Fiacre Bagnaka
Mefo'o, Jean Pierre Nda
Nga, Winnie Tatiana Bekolo
Kenfack, Gabin Ulrich
Yakana, Linus
Malongue, Agnès
Okalla, Cecile
Kowo, Mathurin
Andoulo, Firmin Ankoune
Tzeuton, Christian
Bidja, Marie Solange Doualla
Namme, Henry Luma
Adiogo, Dieudonne
Noah, Dominique Noah
author_facet Eloumou, Servais Albert Fiacre Bagnaka
Mefo'o, Jean Pierre Nda
Nga, Winnie Tatiana Bekolo
Kenfack, Gabin Ulrich
Yakana, Linus
Malongue, Agnès
Okalla, Cecile
Kowo, Mathurin
Andoulo, Firmin Ankoune
Tzeuton, Christian
Bidja, Marie Solange Doualla
Namme, Henry Luma
Adiogo, Dieudonne
Noah, Dominique Noah
author_sort Eloumou, Servais Albert Fiacre Bagnaka
collection PubMed
description INTRODUCTION: hepatitis C virus (HCV) has several extra-hepatic manifestations including cryoglubulinemia. Cryoglobulinemia is defined as the abnormal presence in the blood of one or several proteins (cryoglobulins) that can precipitate at low temperatures. METHOD: We conducted a cross-sectional analytical study in the Laboratory of Biology and in the Unit of Hepatology of the General Hospital in Douala (HGD) over a period of 6 months. All patients agreeing to participate to the study and with anti-hepatitis-C antibodies under treatment or not were enrolled. Cryoglobulins were detected using biuret method and the classification was performed using Brouet immunoelectrophoresis. A multivariate analysis was conducted, confounding factors such as age, sex and the length of time after Hepatitis C Virus screening were adjusted. RESULTS: The study enrolled 116 patients. The average age of patients was 58.47±9.95 years. Male sex accounted for 50.86% of cases. Arthralgia was found in 69.80% of cases. Cryoglobulin was found in 63.80% of patients. After adjustment, female sex (OR =2.18; CI 95% [0,97-4,90]; p= 0.059), asthenia alone (OR =2.45;CI 95% [1,04-5,80]; p= 0.041), asthenia combined with arthralgia (OR =2.84;CI 95% [1,13-7, 10]; p= 0.026) and the presence of HCV RNA (OR =2.84;CI 95% [1,13-7,10]; p= 0.028) were factors independently associated with the presence of cryoglobulin. CONCLUSION: The prevalence of cryoglobubin is high in patients with anti-hepatitis-C antibodies at the HGD. Simple biological methods are used to detect it. Cryoglobulin test in patients with HCV is essential in resource-limited countries.
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spelling pubmed-67567982019-09-27 Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées Eloumou, Servais Albert Fiacre Bagnaka Mefo'o, Jean Pierre Nda Nga, Winnie Tatiana Bekolo Kenfack, Gabin Ulrich Yakana, Linus Malongue, Agnès Okalla, Cecile Kowo, Mathurin Andoulo, Firmin Ankoune Tzeuton, Christian Bidja, Marie Solange Doualla Namme, Henry Luma Adiogo, Dieudonne Noah, Dominique Noah Pan Afr Med J Research INTRODUCTION: hepatitis C virus (HCV) has several extra-hepatic manifestations including cryoglubulinemia. Cryoglobulinemia is defined as the abnormal presence in the blood of one or several proteins (cryoglobulins) that can precipitate at low temperatures. METHOD: We conducted a cross-sectional analytical study in the Laboratory of Biology and in the Unit of Hepatology of the General Hospital in Douala (HGD) over a period of 6 months. All patients agreeing to participate to the study and with anti-hepatitis-C antibodies under treatment or not were enrolled. Cryoglobulins were detected using biuret method and the classification was performed using Brouet immunoelectrophoresis. A multivariate analysis was conducted, confounding factors such as age, sex and the length of time after Hepatitis C Virus screening were adjusted. RESULTS: The study enrolled 116 patients. The average age of patients was 58.47±9.95 years. Male sex accounted for 50.86% of cases. Arthralgia was found in 69.80% of cases. Cryoglobulin was found in 63.80% of patients. After adjustment, female sex (OR =2.18; CI 95% [0,97-4,90]; p= 0.059), asthenia alone (OR =2.45;CI 95% [1,04-5,80]; p= 0.041), asthenia combined with arthralgia (OR =2.84;CI 95% [1,13-7, 10]; p= 0.026) and the presence of HCV RNA (OR =2.84;CI 95% [1,13-7,10]; p= 0.028) were factors independently associated with the presence of cryoglobulin. CONCLUSION: The prevalence of cryoglobubin is high in patients with anti-hepatitis-C antibodies at the HGD. Simple biological methods are used to detect it. Cryoglobulin test in patients with HCV is essential in resource-limited countries. The African Field Epidemiology Network 2019-07-04 /pmc/articles/PMC6756798/ /pubmed/31565130 http://dx.doi.org/10.11604/pamj.2019.33.169.19162 Text en © Servais Albert Fiacre Eloumou Bagnaka et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Eloumou, Servais Albert Fiacre Bagnaka
Mefo'o, Jean Pierre Nda
Nga, Winnie Tatiana Bekolo
Kenfack, Gabin Ulrich
Yakana, Linus
Malongue, Agnès
Okalla, Cecile
Kowo, Mathurin
Andoulo, Firmin Ankoune
Tzeuton, Christian
Bidja, Marie Solange Doualla
Namme, Henry Luma
Adiogo, Dieudonne
Noah, Dominique Noah
Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées
title Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées
title_full Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées
title_fullStr Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées
title_full_unstemmed Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées
title_short Cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite C dans un pays à ressources limitées
title_sort cryoglobuline et facteurs associés chez le patient porteur de l'anticorps du virus de l'hépatite c dans un pays à ressources limitées
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756798/
https://www.ncbi.nlm.nih.gov/pubmed/31565130
http://dx.doi.org/10.11604/pamj.2019.33.169.19162
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