Cargando…

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions

Among the many factors that promote cellular senescence, reactive oxygen species (ROS) are a focus of intense research because of their critical role in accelerating cellular senescence and initiating senescence-related diseases that can be fatal. Therefore, maintaining the proper balance of ROS in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chae, Unbin, Park, Jeen-Woo, Lee, Sang-Rae, Lee, Hong Jun, Lee, Hyun-Shik, Lee, Dong-Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756887/ https://www.ncbi.nlm.nih.gov/pubmed/31503005 http://dx.doi.org/10.18632/aging.102259

Ejemplares similares

IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis
por: Park, Jung Hyun, et al.
Publicado: (2018)

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis
por: Cha, Hanvit, et al.
Publicado: (2017)

Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration
por: Park, Jung Hyun, et al.
Publicado: (2017)

IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury
por: Han, Sang Jun, et al.
Publicado: (2017)

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency
por: Kim, Ye-Ri, et al.
Publicado: (2018)

IDH2 Deficiency Promotes Endothelial Senescence by Eliciting miR-34b/c-Mediated Suppression of Mitophagy and Increased ROS Production
por: Lee, Ikjun, et al.
Publicado: (2023)

Effect of Ulinastatin on Syndecan-2-Mediated Vascular Damage in IDH2-Deficient Endothelial Cells
por: Choi, Su-jeong, et al.
Publicado: (2022)

IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice
por: Pan, Jeong Hoon, et al.
Publicado: (2018)

Senescence, Stress, and Reactive Oxygen Species
por: Jajic, Ivan, et al.
Publicado: (2015)

2-Hydroxymelatonin, Rather Than Melatonin, Is Responsible for RBOH-Dependent Reactive Oxygen Species Production Leading to Premature Senescence in Plants
por: Lee, Hyoung Yool, et al.
Publicado: (2021)

IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle
por: Pan, Jeong Hoon, et al.
Publicado: (2020)

A negative feedback loop between XBP1 and Fbw7 regulates cancer development
por: Chae, Unbin, et al.
Publicado: (2019)

Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence
por: Park, Young-Ho, et al.
Publicado: (2017)

Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review
por: Yuile, Alexander, et al.
Publicado: (2022)

Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
por: Chae, Unbin, et al.
Publicado: (2021)

Cdk2: a key regulator of the senescence control function of Myc
por: Hydbring, Per, et al.
Publicado: (2010)

Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence
por: Pandey, Kamal, et al.
Publicado: (2020)

Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma
por: Krell, Daniel, et al.
Publicado: (2011)

IDH2 gene deficiency accelerates unilateral ureteral obstruction-induced kidney inflammation through oxidative stress and activation of macrophages
por: Kim, Jee In, et al.
Publicado: (2021)

Mechanism of p27 Unfolding for CDK2 Reactivation
por: Rath, Soumya Lipsa, et al.
Publicado: (2016)

Peroxiredoxin I maintains luteal function by regulating unfolded protein response
por: Park, Hyo-Jin, et al.
Publicado: (2018)

Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
por: White, Karessa, et al.
Publicado: (2018)

Residual Cdk1/2 activity after DNA damage promotes senescence
por: Müllers, Erik, et al.
Publicado: (2017)

Paradoxical delay of senescence upon depletion of BRCA2 in telomerase‐deficient worms
por: Kwon, Mi‐Sun, et al.
Publicado: (2016)

Damaged DNA Binding Protein 2 in Reactive Oxygen Species (ROS) Regulation and Premature Senescence
por: Roy, Nilotpal, et al.
Publicado: (2012)

Enhanced ferroelectric switching speed of Si-doped HfO(2) thin film tailored by oxygen deficiency
por: Lee, Kyoungjun, et al.
Publicado: (2021)

IDH1/IDH2 Inhibition in Acute Myeloid Leukemia
por: Cerchione, Claudio, et al.
Publicado: (2021)

The Long-lasting Radioprotective Effect of Caffeic Acid in Mice Exposed to Total Body Irradiation by Modulating Reactive Oxygen Species Generation and Hematopoietic Stem Cell Senescence-Accompanied Long-term Residual Bone Marrow Injury
por: Sim, Hyun-Jaung, et al.
Publicado: (2019)

Chronophin activation is necessary in Doxorubicin-induced actin cytoskeleton alteration
por: Lee, Su Jin, et al.
Publicado: (2017)

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity
por: Pogacar, Ziva, et al.
Publicado: (2022)

Regulation of Reactive Oxygen Species Promotes Growth and Carotenoid Production Under Autotrophic Conditions in Rhodobacter sphaeroides
por: Lee, Yu Rim, et al.
Publicado: (2022)

CDK4/6 inhibitor: from quiescence to senescence
por: Yoshida, Akihiro, et al.
Publicado: (2015)

7-Ketocholesterol accelerates pancreatic β-cell senescence by inhibiting the SIRT1/CDK4–Rb–E2F1 signaling pathway
por: Zhu, Qiuping, et al.
Publicado: (2023)

Intrahepatic cholangiocarcinomas with IDH1/2 mutation-associated hypermethylation at selective genes and their clinicopathological features
por: Lee, Kyoungbun, et al.
Publicado: (2020)

Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction
por: Yu, Dong‐Min, et al.
Publicado: (2017)

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence
por: Brookes, Sharon, et al.
Publicado: (2015)

IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
por: DiNardo, Courtney D, et al.
Publicado: (2015)

IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
por: Mondesir, Johanna, et al.
Publicado: (2016)

IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution
por: Rodriguez, Erika F., et al.
Publicado: (2020)

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL
por: Simonin, Mathieu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3bdajqbhkr5h9c4hbagc3l6i1a