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The activation of cardiac dSir2-related pathways mediates physical exercise resistance to heart aging in old Drosophila
Cardiac aging is majorly characterized by increased diastolic dysfunction, lipid accumulation, oxidative stress, and contractility debility. The Sir2/Sirt1 gene overexpression delays cell aging and reduces obesity and oxidative stress. Exercise improves heart function and delays heart aging. However...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756900/ https://www.ncbi.nlm.nih.gov/pubmed/31503544 http://dx.doi.org/10.18632/aging.102261 |