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Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis
Data regarding the association between subclinical thyroid dysfunction and clinical outcomes in ischemic stroke patients with intravenous thrombolysis (IVT) are limited. We aimed to investigate the predictive value of subclinical thyroid dysfunction in END, functional outcome and mortality at 3 mont...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756908/ https://www.ncbi.nlm.nih.gov/pubmed/31479421 http://dx.doi.org/10.18632/aging.102215 |
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author | Zhang, Xiaohao Gong, Pengyu Sheng, Lei Lin, Yanni Fan, Qiqi Zhang, Yun Bao, Yuanfei Li, Shizhan Du, Hongcai Chen, Zhonglun Ding, Caixia Wang, Huaiming Xu, Pengfei Zhang, Min Scalzo, Fabien Liebeskind, David S. Xie, Yi Liu, Dezhi |
author_facet | Zhang, Xiaohao Gong, Pengyu Sheng, Lei Lin, Yanni Fan, Qiqi Zhang, Yun Bao, Yuanfei Li, Shizhan Du, Hongcai Chen, Zhonglun Ding, Caixia Wang, Huaiming Xu, Pengfei Zhang, Min Scalzo, Fabien Liebeskind, David S. Xie, Yi Liu, Dezhi |
author_sort | Zhang, Xiaohao |
collection | PubMed |
description | Data regarding the association between subclinical thyroid dysfunction and clinical outcomes in ischemic stroke patients with intravenous thrombolysis (IVT) are limited. We aimed to investigate the predictive value of subclinical thyroid dysfunction in END, functional outcome and mortality at 3 months among IVT patients. We prospectively recruited 563 IVT patients from 5 stroke centers in China. Thyroid function status was classified as subclinical hypothyroidism, subclinical hyperthyroidism (SHyper) and euthyroidism. The primary outcome was END, defined as ≥ 4 point in the NIHSS score within 24 h after IVT. Secondary outcomes included 3-month functional outcome and mortality. Of the 563 participants, END occurred in 14.7%, poor outcome in 50.8%, and mortality in 9.4%. SHyper was an independent predictor of END [odd ratio (OR), 4.35; 95% confidence interval [CI], 1.86–9.68, P = 0.003], 3-month poor outcome (OR, 3.24; 95% CI, 1.43–7.33, P = 0.005) and mortality [hazard ratio, 2.78; 95% CI, 1.55–5.36, P = 0.003]. Subgroup analysis showed that there was no significant relationship between SHyper and clinical outcomes in IVT patients with endovascular therapy. In summary, SHyper is associated with increased risk of END, and poor outcome and mortality at 3 months in IVT patients without endovascular therapy. |
format | Online Article Text |
id | pubmed-6756908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-67569082019-09-27 Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis Zhang, Xiaohao Gong, Pengyu Sheng, Lei Lin, Yanni Fan, Qiqi Zhang, Yun Bao, Yuanfei Li, Shizhan Du, Hongcai Chen, Zhonglun Ding, Caixia Wang, Huaiming Xu, Pengfei Zhang, Min Scalzo, Fabien Liebeskind, David S. Xie, Yi Liu, Dezhi Aging (Albany NY) Research Paper Data regarding the association between subclinical thyroid dysfunction and clinical outcomes in ischemic stroke patients with intravenous thrombolysis (IVT) are limited. We aimed to investigate the predictive value of subclinical thyroid dysfunction in END, functional outcome and mortality at 3 months among IVT patients. We prospectively recruited 563 IVT patients from 5 stroke centers in China. Thyroid function status was classified as subclinical hypothyroidism, subclinical hyperthyroidism (SHyper) and euthyroidism. The primary outcome was END, defined as ≥ 4 point in the NIHSS score within 24 h after IVT. Secondary outcomes included 3-month functional outcome and mortality. Of the 563 participants, END occurred in 14.7%, poor outcome in 50.8%, and mortality in 9.4%. SHyper was an independent predictor of END [odd ratio (OR), 4.35; 95% confidence interval [CI], 1.86–9.68, P = 0.003], 3-month poor outcome (OR, 3.24; 95% CI, 1.43–7.33, P = 0.005) and mortality [hazard ratio, 2.78; 95% CI, 1.55–5.36, P = 0.003]. Subgroup analysis showed that there was no significant relationship between SHyper and clinical outcomes in IVT patients with endovascular therapy. In summary, SHyper is associated with increased risk of END, and poor outcome and mortality at 3 months in IVT patients without endovascular therapy. Impact Journals 2019-09-03 /pmc/articles/PMC6756908/ /pubmed/31479421 http://dx.doi.org/10.18632/aging.102215 Text en Copyright © 2019 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhang, Xiaohao Gong, Pengyu Sheng, Lei Lin, Yanni Fan, Qiqi Zhang, Yun Bao, Yuanfei Li, Shizhan Du, Hongcai Chen, Zhonglun Ding, Caixia Wang, Huaiming Xu, Pengfei Zhang, Min Scalzo, Fabien Liebeskind, David S. Xie, Yi Liu, Dezhi Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
title | Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
title_full | Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
title_fullStr | Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
title_full_unstemmed | Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
title_short | Prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
title_sort | prognostic value of subclinical thyroid dysfunction in ischemic stroke patients treated with intravenous thrombolysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756908/ https://www.ncbi.nlm.nih.gov/pubmed/31479421 http://dx.doi.org/10.18632/aging.102215 |
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