Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli

Diverse stress insults trigger interactions of PML with nucleolus, however, the function of these PML nucleolar associations (PNAs) remains unclear. Here we show that during induction of DNA damage-induced senescence in human non-cancerous cells, PML accumulates at the nucleolar periphery simultaneo...

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Detalles Bibliográficos
Autores principales: Imrichova, Terezie, Hubackova, Sona, Kucerova, Alena, Kosla, Jan, Bartek, Jiri, Hodny, Zdenek, Vasicova, Pavla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756913/
https://www.ncbi.nlm.nih.gov/pubmed/31493766
http://dx.doi.org/10.18632/aging.102248

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