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Aseptic meningitis caused by torque teno virus in an infant: a case report

BACKGROUND: Torque teno virus-induced aseptic meningitis has not been documented, although torque teno virus infections still remain under consideration for etiological agents. This study identified a torque teno virus sequence using next generation sequencing and immunoglobulin M response to the to...

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Autores principales: Ikuta, Yoji, Oba, Kunihiro, Nai, Emina, Katori, Tatsuo, Hashino, Masanori, Inamine, Yuba, Matsunaga, Satoko, Yamaoka, Yutaro, Sekizuka, Tsuyoshi, Ryo, Akihide, Kuroda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757355/
https://www.ncbi.nlm.nih.gov/pubmed/31547860
http://dx.doi.org/10.1186/s13256-019-2233-2
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author Ikuta, Yoji
Oba, Kunihiro
Nai, Emina
Katori, Tatsuo
Hashino, Masanori
Inamine, Yuba
Matsunaga, Satoko
Yamaoka, Yutaro
Sekizuka, Tsuyoshi
Ryo, Akihide
Kuroda, Makoto
author_facet Ikuta, Yoji
Oba, Kunihiro
Nai, Emina
Katori, Tatsuo
Hashino, Masanori
Inamine, Yuba
Matsunaga, Satoko
Yamaoka, Yutaro
Sekizuka, Tsuyoshi
Ryo, Akihide
Kuroda, Makoto
author_sort Ikuta, Yoji
collection PubMed
description BACKGROUND: Torque teno virus-induced aseptic meningitis has not been documented, although torque teno virus infections still remain under consideration for etiological agents. This study identified a torque teno virus sequence using next generation sequencing and immunoglobulin M response to the torque teno virus antigen, therefore, that would be a comprehensive diagnosis for torque teno virus infection. CASE PRESENTATION: A 2-month-old Japanese boy was brought to our hospital because he was irritable, drowsy, and lethargic. He was admitted based on his test results which indicated the possibility of septic meningitis. He was started on treatment with high-dose antibiotics and steroids. On the third day of hospitalization, he became afebrile with improvement in his general status and was discharged on the sixth day. He had no developmental problems for up to 1 year after discharge. Metagenomic ribonucleic acid-Seq pathogen detection using next generation sequencing of a sample of his cerebrospinal fluid, which was collected at admission, revealed three short reads homologous to those in torque teno virus out of a total of 1,708,516 reads. This finding indicated that our patient was positive compared to the torque teno virus-negative cerebrospinal fluid samples (controls) from 13 other patients. The torque teno virus has been shown to have a whole genome sequence of 2810 nt by polymerase chain reaction. We prepared a recombinant GP2 antigen from torque teno virus and used it to study our patient’s anti-torque teno virus immune response. An anti-GP2 serum immunoglobulin M response was detected, providing further supportive evidence of torque teno virus infection. CONCLUSIONS: This case speculates that torque teno virus-induced aseptic meningitis has a good course. New technologies like next generation sequencing can help in the identification of such cases, and an accumulation of future cases is expected.
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spelling pubmed-67573552019-09-30 Aseptic meningitis caused by torque teno virus in an infant: a case report Ikuta, Yoji Oba, Kunihiro Nai, Emina Katori, Tatsuo Hashino, Masanori Inamine, Yuba Matsunaga, Satoko Yamaoka, Yutaro Sekizuka, Tsuyoshi Ryo, Akihide Kuroda, Makoto J Med Case Rep Case Report BACKGROUND: Torque teno virus-induced aseptic meningitis has not been documented, although torque teno virus infections still remain under consideration for etiological agents. This study identified a torque teno virus sequence using next generation sequencing and immunoglobulin M response to the torque teno virus antigen, therefore, that would be a comprehensive diagnosis for torque teno virus infection. CASE PRESENTATION: A 2-month-old Japanese boy was brought to our hospital because he was irritable, drowsy, and lethargic. He was admitted based on his test results which indicated the possibility of septic meningitis. He was started on treatment with high-dose antibiotics and steroids. On the third day of hospitalization, he became afebrile with improvement in his general status and was discharged on the sixth day. He had no developmental problems for up to 1 year after discharge. Metagenomic ribonucleic acid-Seq pathogen detection using next generation sequencing of a sample of his cerebrospinal fluid, which was collected at admission, revealed three short reads homologous to those in torque teno virus out of a total of 1,708,516 reads. This finding indicated that our patient was positive compared to the torque teno virus-negative cerebrospinal fluid samples (controls) from 13 other patients. The torque teno virus has been shown to have a whole genome sequence of 2810 nt by polymerase chain reaction. We prepared a recombinant GP2 antigen from torque teno virus and used it to study our patient’s anti-torque teno virus immune response. An anti-GP2 serum immunoglobulin M response was detected, providing further supportive evidence of torque teno virus infection. CONCLUSIONS: This case speculates that torque teno virus-induced aseptic meningitis has a good course. New technologies like next generation sequencing can help in the identification of such cases, and an accumulation of future cases is expected. BioMed Central 2019-09-24 /pmc/articles/PMC6757355/ /pubmed/31547860 http://dx.doi.org/10.1186/s13256-019-2233-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Ikuta, Yoji
Oba, Kunihiro
Nai, Emina
Katori, Tatsuo
Hashino, Masanori
Inamine, Yuba
Matsunaga, Satoko
Yamaoka, Yutaro
Sekizuka, Tsuyoshi
Ryo, Akihide
Kuroda, Makoto
Aseptic meningitis caused by torque teno virus in an infant: a case report
title Aseptic meningitis caused by torque teno virus in an infant: a case report
title_full Aseptic meningitis caused by torque teno virus in an infant: a case report
title_fullStr Aseptic meningitis caused by torque teno virus in an infant: a case report
title_full_unstemmed Aseptic meningitis caused by torque teno virus in an infant: a case report
title_short Aseptic meningitis caused by torque teno virus in an infant: a case report
title_sort aseptic meningitis caused by torque teno virus in an infant: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757355/
https://www.ncbi.nlm.nih.gov/pubmed/31547860
http://dx.doi.org/10.1186/s13256-019-2233-2
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