Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major stromal cell type in the HCC microenvironment, promote HCC progression, and have gradually become a hot research topic in HCC...

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Autores principales: Yin, Zeli, Dong, Chengyong, Jiang, Keqiu, Xu, Zhe, Li, Rui, Guo, Kun, Shao, Shujuan, Wang, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757399/
https://www.ncbi.nlm.nih.gov/pubmed/31547836
http://dx.doi.org/10.1186/s13045-019-0782-x
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author Yin, Zeli
Dong, Chengyong
Jiang, Keqiu
Xu, Zhe
Li, Rui
Guo, Kun
Shao, Shujuan
Wang, Liming
author_facet Yin, Zeli
Dong, Chengyong
Jiang, Keqiu
Xu, Zhe
Li, Rui
Guo, Kun
Shao, Shujuan
Wang, Liming
author_sort Yin, Zeli
collection PubMed
description Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major stromal cell type in the HCC microenvironment, promote HCC progression, and have gradually become a hot research topic in HCC-targeted therapy. This review comprehensively describes and discusses the heterogeneous tissue distribution, cellular origin, phenotype, and biological functions of HCC-associated fibroblasts. Furthermore, the possible use of CAFs for predicting HCC prognosis and in targeted therapeutic strategies is discussed, highlighting the critical roles of CAFs in HCC progression, diagnosis, and therapy.
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spelling pubmed-67573992019-09-30 Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma Yin, Zeli Dong, Chengyong Jiang, Keqiu Xu, Zhe Li, Rui Guo, Kun Shao, Shujuan Wang, Liming J Hematol Oncol Review Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major stromal cell type in the HCC microenvironment, promote HCC progression, and have gradually become a hot research topic in HCC-targeted therapy. This review comprehensively describes and discusses the heterogeneous tissue distribution, cellular origin, phenotype, and biological functions of HCC-associated fibroblasts. Furthermore, the possible use of CAFs for predicting HCC prognosis and in targeted therapeutic strategies is discussed, highlighting the critical roles of CAFs in HCC progression, diagnosis, and therapy. BioMed Central 2019-09-23 /pmc/articles/PMC6757399/ /pubmed/31547836 http://dx.doi.org/10.1186/s13045-019-0782-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yin, Zeli
Dong, Chengyong
Jiang, Keqiu
Xu, Zhe
Li, Rui
Guo, Kun
Shao, Shujuan
Wang, Liming
Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
title Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
title_full Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
title_fullStr Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
title_full_unstemmed Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
title_short Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
title_sort heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757399/
https://www.ncbi.nlm.nih.gov/pubmed/31547836
http://dx.doi.org/10.1186/s13045-019-0782-x
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