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Genetic Vulnerability to Experiencing Child Maltreatment

Although biological factors may influence the risk of experiencing negative life events, the role of genes in the vulnerability to child victimization remains poorly understood. In a large population-based Finnish sample (N = 13,024), we retrospectively measured multiple experiences of child victimi...

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Autores principales: Pezzoli, Patrizia, Antfolk, Jan, Hatoum, Alexander S., Santtila, Pekka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758596/
https://www.ncbi.nlm.nih.gov/pubmed/31608106
http://dx.doi.org/10.3389/fgene.2019.00852
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author Pezzoli, Patrizia
Antfolk, Jan
Hatoum, Alexander S.
Santtila, Pekka
author_facet Pezzoli, Patrizia
Antfolk, Jan
Hatoum, Alexander S.
Santtila, Pekka
author_sort Pezzoli, Patrizia
collection PubMed
description Although biological factors may influence the risk of experiencing negative life events, the role of genes in the vulnerability to child victimization remains poorly understood. In a large population-based Finnish sample (N = 13,024), we retrospectively measured multiple experiences of child victimization and, in a subsample of twins (n = 9,562), we estimated the extent to which genetic and environmental factors influenced these experiences. In particular, we investigated whether genetic and environmental influences varied depending on the type of child victimization, the genetic relatedness with the perpetrator, and the sex of the victim. Our quantitative genetic analyses supported the presence of both genetic and environmental influences on the occurrence and co-occurrence of child abuse and neglect. We also identified one common etiological pathway underlying multiple child victimizations, and after accounting for this common etiology, we singled out risk factors specific to sexual abuse. Environmental factors shared and nonshared between twins raised together influenced the risk of victimization by genetically related and unrelated perpetrators, respectively. Furthermore, we estimated sex differences in the etiology of emotional and sexual victimization, including larger unshared environmental influences for men and sex-limited genetic effects for women. These findings can inform child protection as they contribute to explaining why certain individuals are at increased risk of experiencing one or more types of child maltreatment.
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spelling pubmed-67585962019-10-11 Genetic Vulnerability to Experiencing Child Maltreatment Pezzoli, Patrizia Antfolk, Jan Hatoum, Alexander S. Santtila, Pekka Front Genet Genetics Although biological factors may influence the risk of experiencing negative life events, the role of genes in the vulnerability to child victimization remains poorly understood. In a large population-based Finnish sample (N = 13,024), we retrospectively measured multiple experiences of child victimization and, in a subsample of twins (n = 9,562), we estimated the extent to which genetic and environmental factors influenced these experiences. In particular, we investigated whether genetic and environmental influences varied depending on the type of child victimization, the genetic relatedness with the perpetrator, and the sex of the victim. Our quantitative genetic analyses supported the presence of both genetic and environmental influences on the occurrence and co-occurrence of child abuse and neglect. We also identified one common etiological pathway underlying multiple child victimizations, and after accounting for this common etiology, we singled out risk factors specific to sexual abuse. Environmental factors shared and nonshared between twins raised together influenced the risk of victimization by genetically related and unrelated perpetrators, respectively. Furthermore, we estimated sex differences in the etiology of emotional and sexual victimization, including larger unshared environmental influences for men and sex-limited genetic effects for women. These findings can inform child protection as they contribute to explaining why certain individuals are at increased risk of experiencing one or more types of child maltreatment. Frontiers Media S.A. 2019-09-17 /pmc/articles/PMC6758596/ /pubmed/31608106 http://dx.doi.org/10.3389/fgene.2019.00852 Text en Copyright © 2019 Pezzoli, Antfolk, Hatoum and Santtila http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Pezzoli, Patrizia
Antfolk, Jan
Hatoum, Alexander S.
Santtila, Pekka
Genetic Vulnerability to Experiencing Child Maltreatment
title Genetic Vulnerability to Experiencing Child Maltreatment
title_full Genetic Vulnerability to Experiencing Child Maltreatment
title_fullStr Genetic Vulnerability to Experiencing Child Maltreatment
title_full_unstemmed Genetic Vulnerability to Experiencing Child Maltreatment
title_short Genetic Vulnerability to Experiencing Child Maltreatment
title_sort genetic vulnerability to experiencing child maltreatment
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758596/
https://www.ncbi.nlm.nih.gov/pubmed/31608106
http://dx.doi.org/10.3389/fgene.2019.00852
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