Autoactivation of small GTPases by the GEF–effector positive feedback modules

Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the u...

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Detalles Bibliográficos
Autores principales: Goryachev, Andrew B., Leda, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758843/
https://www.ncbi.nlm.nih.gov/pubmed/31583084
http://dx.doi.org/10.12688/f1000research.20003.1
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author Goryachev, Andrew B.
Leda, Marcin
author_facet Goryachev, Andrew B.
Leda, Marcin
author_sort Goryachev, Andrew B.
collection PubMed
description Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology.
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spelling pubmed-67588432019-10-02 Autoactivation of small GTPases by the GEF–effector positive feedback modules Goryachev, Andrew B. Leda, Marcin F1000Res Review Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF–effector feedback modules and survey recent developments in this exciting area of cell biology. F1000 Research Limited 2019-09-23 /pmc/articles/PMC6758843/ /pubmed/31583084 http://dx.doi.org/10.12688/f1000research.20003.1 Text en Copyright: © 2019 Goryachev AB and Leda M http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Goryachev, Andrew B.
Leda, Marcin
Autoactivation of small GTPases by the GEF–effector positive feedback modules
title Autoactivation of small GTPases by the GEF–effector positive feedback modules
title_full Autoactivation of small GTPases by the GEF–effector positive feedback modules
title_fullStr Autoactivation of small GTPases by the GEF–effector positive feedback modules
title_full_unstemmed Autoactivation of small GTPases by the GEF–effector positive feedback modules
title_short Autoactivation of small GTPases by the GEF–effector positive feedback modules
title_sort autoactivation of small gtpases by the gef–effector positive feedback modules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758843/
https://www.ncbi.nlm.nih.gov/pubmed/31583084
http://dx.doi.org/10.12688/f1000research.20003.1
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