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Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma
Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. Histologically it consists...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758965/ https://www.ncbi.nlm.nih.gov/pubmed/31565596 http://dx.doi.org/10.7759/cureus.5188 |
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author | Koufopoulos, Nektarios Kokkali, Stefania Antoniadou, Foteini Dimas, Dionysios T Missitzis, Ioannis L |
author_facet | Koufopoulos, Nektarios Kokkali, Stefania Antoniadou, Foteini Dimas, Dionysios T Missitzis, Ioannis L |
author_sort | Koufopoulos, Nektarios |
collection | PubMed |
description | Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. Histologically it consists of invasive carcinoma of no special type with transition to cartilaginous or osseous matrix without a spindle cell component. Data on this entity are limited with the literature consisting mostly of case reports and a small number of case series. We report a case of matrix-producing breast carcinoma, with excellent clinical outcome. We also discuss the histogenesis, imaging, histological, and immunohistochemical characteristics, treatment, and focus on the differential diagnosis of this rare tumor. |
format | Online Article Text |
id | pubmed-6758965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-67589652019-09-28 Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma Koufopoulos, Nektarios Kokkali, Stefania Antoniadou, Foteini Dimas, Dionysios T Missitzis, Ioannis L Cureus Pathology Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. Histologically it consists of invasive carcinoma of no special type with transition to cartilaginous or osseous matrix without a spindle cell component. Data on this entity are limited with the literature consisting mostly of case reports and a small number of case series. We report a case of matrix-producing breast carcinoma, with excellent clinical outcome. We also discuss the histogenesis, imaging, histological, and immunohistochemical characteristics, treatment, and focus on the differential diagnosis of this rare tumor. Cureus 2019-07-22 /pmc/articles/PMC6758965/ /pubmed/31565596 http://dx.doi.org/10.7759/cureus.5188 Text en Copyright © 2019, Koufopoulos et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Koufopoulos, Nektarios Kokkali, Stefania Antoniadou, Foteini Dimas, Dionysios T Missitzis, Ioannis L Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma |
title | Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma |
title_full | Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma |
title_fullStr | Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma |
title_full_unstemmed | Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma |
title_short | Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma |
title_sort | matrix-producing breast carcinoma: a rare subtype of metaplastic breast carcinoma |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758965/ https://www.ncbi.nlm.nih.gov/pubmed/31565596 http://dx.doi.org/10.7759/cureus.5188 |
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