Cargando…

Anti-N-methyl-D-aspartate Receptor Encephalitis

Anti-N-methyl-D-aspartate receptor (NMDA) encephalitis is an underrecognized encephalitis that may be mistaken for a wide variety of mental illnesses and causes of delirium. This syndrome is predominantly present in young females presenting with acute psychotic episodes, autonomic instability, and n...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanquary, Gregory, Fraser, William, Bowers, Kaitlin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759002/
https://www.ncbi.nlm.nih.gov/pubmed/31565599
http://dx.doi.org/10.7759/cureus.5192
_version_ 1783453623632527360
author Tanquary, Gregory
Fraser, William
Bowers, Kaitlin M
author_facet Tanquary, Gregory
Fraser, William
Bowers, Kaitlin M
author_sort Tanquary, Gregory
collection PubMed
description Anti-N-methyl-D-aspartate receptor (NMDA) encephalitis is an underrecognized encephalitis that may be mistaken for a wide variety of mental illnesses and causes of delirium. This syndrome is predominantly present in young females presenting with acute psychotic episodes, autonomic instability, and neurologic abnormalities. It is commonly associated with ovarian teratoma. Our case illustrates anti-NMDA encephalitis presenting in a young female with progressive mental status changes and neurologic abnormalities throughout her emergency department course. We review the investigative approach, diagnostic modalities, and treatment options in patient management. This case emphasizes the need for a high index of suspicion of anti-NMDA receptor encephalitis when approaching a patient with unexplained changes in mentation.
format Online
Article
Text
id pubmed-6759002
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-67590022019-09-28 Anti-N-methyl-D-aspartate Receptor Encephalitis Tanquary, Gregory Fraser, William Bowers, Kaitlin M Cureus Emergency Medicine Anti-N-methyl-D-aspartate receptor (NMDA) encephalitis is an underrecognized encephalitis that may be mistaken for a wide variety of mental illnesses and causes of delirium. This syndrome is predominantly present in young females presenting with acute psychotic episodes, autonomic instability, and neurologic abnormalities. It is commonly associated with ovarian teratoma. Our case illustrates anti-NMDA encephalitis presenting in a young female with progressive mental status changes and neurologic abnormalities throughout her emergency department course. We review the investigative approach, diagnostic modalities, and treatment options in patient management. This case emphasizes the need for a high index of suspicion of anti-NMDA receptor encephalitis when approaching a patient with unexplained changes in mentation. Cureus 2019-07-22 /pmc/articles/PMC6759002/ /pubmed/31565599 http://dx.doi.org/10.7759/cureus.5192 Text en Copyright © 2019, Tanquary et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Tanquary, Gregory
Fraser, William
Bowers, Kaitlin M
Anti-N-methyl-D-aspartate Receptor Encephalitis
title Anti-N-methyl-D-aspartate Receptor Encephalitis
title_full Anti-N-methyl-D-aspartate Receptor Encephalitis
title_fullStr Anti-N-methyl-D-aspartate Receptor Encephalitis
title_full_unstemmed Anti-N-methyl-D-aspartate Receptor Encephalitis
title_short Anti-N-methyl-D-aspartate Receptor Encephalitis
title_sort anti-n-methyl-d-aspartate receptor encephalitis
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759002/
https://www.ncbi.nlm.nih.gov/pubmed/31565599
http://dx.doi.org/10.7759/cureus.5192
work_keys_str_mv AT tanquarygregory antinmethyldaspartatereceptorencephalitis
AT fraserwilliam antinmethyldaspartatereceptorencephalitis
AT bowerskaitlinm antinmethyldaspartatereceptorencephalitis