Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines

Ewing Sarcoma (ES) is characterized by recurrent translocations between EWSR1 and members of the ETS family of transcription factors. The transcriptional activity of the fusion oncoprotein is dependent on interaction with the nucleosome remodeling and deactylase (NuRD) co-repressor complex. While in...

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Detalles Bibliográficos
Autores principales: Welch, Darcy, Kahen, Elliot, Fridley, Brooke, Brohl, Andrew S., Cubitt, Christopher L., Reed, Damon R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759167/
https://www.ncbi.nlm.nih.gov/pubmed/31550266
http://dx.doi.org/10.1371/journal.pone.0222228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759167/
https://www.ncbi.nlm.nih.gov/pubmed/31550266
http://dx.doi.org/10.1371/journal.pone.0222228

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