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Incidence of retinal vein occlusion with long-term exposure to ambient air pollution

This study aimed to investigate whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among the population of Taiwan. A retrospective cohort study involving 855,297 people was conducted. Cox proportion...

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Autores principales: Zhang, Han-Wei, Lin, Chao-Wen, Kok, Victor C., Tseng, Chun-Hung, Lin, Yuan-Pei, Li, Tsai-Chung, Sung, Fung-Chang, Wen, Chi Pang, Hsiung, Chao A., Hsu, Chung Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759191/
https://www.ncbi.nlm.nih.gov/pubmed/31550294
http://dx.doi.org/10.1371/journal.pone.0222895
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author Zhang, Han-Wei
Lin, Chao-Wen
Kok, Victor C.
Tseng, Chun-Hung
Lin, Yuan-Pei
Li, Tsai-Chung
Sung, Fung-Chang
Wen, Chi Pang
Hsiung, Chao A.
Hsu, Chung Y.
author_facet Zhang, Han-Wei
Lin, Chao-Wen
Kok, Victor C.
Tseng, Chun-Hung
Lin, Yuan-Pei
Li, Tsai-Chung
Sung, Fung-Chang
Wen, Chi Pang
Hsiung, Chao A.
Hsu, Chung Y.
author_sort Zhang, Han-Wei
collection PubMed
description This study aimed to investigate whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among the population of Taiwan. A retrospective cohort study involving 855,297 people was conducted. Cox proportional hazards regression analysis fitted the multiple pollutant models for two targeted pollutants, including total hydrocarbons (THC), nonmethane hydrocarbons (NMHC) were used, and the risk of RVO was estimated. The chi-squared test and one-way analysis of variance were used to test differences in demographics and comorbidity distribution among tertiles of the targeted pollutants. Before controlling for multiple pollutants, hazard ratios for the overall population were 19.88 (95% CI: 17.56–22.50) at 0.51-ppm increases in THC and 4.33 (95% CI: 3.97–4.73) at 0.27-ppm increases in NMHC. The highest adjusted hazard ratios for different multiple pollutant models of each targeted pollutant were statistically significant (all p values were ≤0.05) for all patients at 29.67 (95% CI: 25.57–34.42) for THC and 16.24 (95% CI: 14.14–18.65) for NMHC. Our findings suggest that long-term exposure to THC and NMHC contribute to RVO development.
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spelling pubmed-67591912019-10-04 Incidence of retinal vein occlusion with long-term exposure to ambient air pollution Zhang, Han-Wei Lin, Chao-Wen Kok, Victor C. Tseng, Chun-Hung Lin, Yuan-Pei Li, Tsai-Chung Sung, Fung-Chang Wen, Chi Pang Hsiung, Chao A. Hsu, Chung Y. PLoS One Research Article This study aimed to investigate whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among the population of Taiwan. A retrospective cohort study involving 855,297 people was conducted. Cox proportional hazards regression analysis fitted the multiple pollutant models for two targeted pollutants, including total hydrocarbons (THC), nonmethane hydrocarbons (NMHC) were used, and the risk of RVO was estimated. The chi-squared test and one-way analysis of variance were used to test differences in demographics and comorbidity distribution among tertiles of the targeted pollutants. Before controlling for multiple pollutants, hazard ratios for the overall population were 19.88 (95% CI: 17.56–22.50) at 0.51-ppm increases in THC and 4.33 (95% CI: 3.97–4.73) at 0.27-ppm increases in NMHC. The highest adjusted hazard ratios for different multiple pollutant models of each targeted pollutant were statistically significant (all p values were ≤0.05) for all patients at 29.67 (95% CI: 25.57–34.42) for THC and 16.24 (95% CI: 14.14–18.65) for NMHC. Our findings suggest that long-term exposure to THC and NMHC contribute to RVO development. Public Library of Science 2019-09-24 /pmc/articles/PMC6759191/ /pubmed/31550294 http://dx.doi.org/10.1371/journal.pone.0222895 Text en © 2019 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Han-Wei
Lin, Chao-Wen
Kok, Victor C.
Tseng, Chun-Hung
Lin, Yuan-Pei
Li, Tsai-Chung
Sung, Fung-Chang
Wen, Chi Pang
Hsiung, Chao A.
Hsu, Chung Y.
Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
title Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
title_full Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
title_fullStr Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
title_full_unstemmed Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
title_short Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
title_sort incidence of retinal vein occlusion with long-term exposure to ambient air pollution
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759191/
https://www.ncbi.nlm.nih.gov/pubmed/31550294
http://dx.doi.org/10.1371/journal.pone.0222895
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