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Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015

To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015...

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Autores principales: Van Kerkhove, Maria D., Alaswad, Sadoof, Assiri, Abdullah, Perera, Ranawaka A.P.M., Peiris, Malik, El Bushra, Hassan E., BinSaeed, Abdulaziz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759265/
https://www.ncbi.nlm.nih.gov/pubmed/31423971
http://dx.doi.org/10.3201/eid2510.190130
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author Van Kerkhove, Maria D.
Alaswad, Sadoof
Assiri, Abdullah
Perera, Ranawaka A.P.M.
Peiris, Malik
El Bushra, Hassan E.
BinSaeed, Abdulaziz A.
author_facet Van Kerkhove, Maria D.
Alaswad, Sadoof
Assiri, Abdullah
Perera, Ranawaka A.P.M.
Peiris, Malik
El Bushra, Hassan E.
BinSaeed, Abdulaziz A.
author_sort Van Kerkhove, Maria D.
collection PubMed
description To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015–January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%–32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low.
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spelling pubmed-67592652019-10-02 Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015 Van Kerkhove, Maria D. Alaswad, Sadoof Assiri, Abdullah Perera, Ranawaka A.P.M. Peiris, Malik El Bushra, Hassan E. BinSaeed, Abdulaziz A. Emerg Infect Dis Synopsis To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015–January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%–32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low. Centers for Disease Control and Prevention 2019-10 /pmc/articles/PMC6759265/ /pubmed/31423971 http://dx.doi.org/10.3201/eid2510.190130 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Van Kerkhove, Maria D.
Alaswad, Sadoof
Assiri, Abdullah
Perera, Ranawaka A.P.M.
Peiris, Malik
El Bushra, Hassan E.
BinSaeed, Abdulaziz A.
Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
title Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
title_full Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
title_fullStr Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
title_full_unstemmed Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
title_short Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
title_sort transmissibility of mers-cov infection in closed setting, riyadh, saudi arabia, 2015
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759265/
https://www.ncbi.nlm.nih.gov/pubmed/31423971
http://dx.doi.org/10.3201/eid2510.190130
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