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VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. W...

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Autores principales: Fonseca, Ana Maria, González, Raquel, Bardají, Azucena, Jairoce, Chenjerai, Rupérez, Maria, Jiménez, Alfons, Quintó, Llorenç, Cisteró, Pau, Vala, Anifa, Sacoor, Charfudin, Gupta, Himanshu, Hegewisch-Taylor, Jennifer, Brew, Joe, Ndam, Nicaise Tuikue, Kariuki, Simon, López, Marta, Dobaño, Carlota, Chitnis, Chetan E., Ouma, Peter, Ramharter, Michael, Abdulla, Salim, Aponte, John J., Massougbodji, Achille, Briand, Valerie, Mombo-Ngoma, Ghyslain, Desai, Meghna, Cot, Michel, Nhacolo, Arsenio, Sevene, Esperança, Macete, Eusebio, Menéndez, Clara, Mayor, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759269/
https://www.ncbi.nlm.nih.gov/pubmed/31538557
http://dx.doi.org/10.3201/eid2510.181177
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author Fonseca, Ana Maria
González, Raquel
Bardají, Azucena
Jairoce, Chenjerai
Rupérez, Maria
Jiménez, Alfons
Quintó, Llorenç
Cisteró, Pau
Vala, Anifa
Sacoor, Charfudin
Gupta, Himanshu
Hegewisch-Taylor, Jennifer
Brew, Joe
Ndam, Nicaise Tuikue
Kariuki, Simon
López, Marta
Dobaño, Carlota
Chitnis, Chetan E.
Ouma, Peter
Ramharter, Michael
Abdulla, Salim
Aponte, John J.
Massougbodji, Achille
Briand, Valerie
Mombo-Ngoma, Ghyslain
Desai, Meghna
Cot, Michel
Nhacolo, Arsenio
Sevene, Esperança
Macete, Eusebio
Menéndez, Clara
Mayor, Alfredo
author_facet Fonseca, Ana Maria
González, Raquel
Bardají, Azucena
Jairoce, Chenjerai
Rupérez, Maria
Jiménez, Alfons
Quintó, Llorenç
Cisteró, Pau
Vala, Anifa
Sacoor, Charfudin
Gupta, Himanshu
Hegewisch-Taylor, Jennifer
Brew, Joe
Ndam, Nicaise Tuikue
Kariuki, Simon
López, Marta
Dobaño, Carlota
Chitnis, Chetan E.
Ouma, Peter
Ramharter, Michael
Abdulla, Salim
Aponte, John J.
Massougbodji, Achille
Briand, Valerie
Mombo-Ngoma, Ghyslain
Desai, Meghna
Cot, Michel
Nhacolo, Arsenio
Sevene, Esperança
Macete, Eusebio
Menéndez, Clara
Mayor, Alfredo
author_sort Fonseca, Ana Maria
collection PubMed
description Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004–2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.
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spelling pubmed-67592692019-10-02 VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy Fonseca, Ana Maria González, Raquel Bardají, Azucena Jairoce, Chenjerai Rupérez, Maria Jiménez, Alfons Quintó, Llorenç Cisteró, Pau Vala, Anifa Sacoor, Charfudin Gupta, Himanshu Hegewisch-Taylor, Jennifer Brew, Joe Ndam, Nicaise Tuikue Kariuki, Simon López, Marta Dobaño, Carlota Chitnis, Chetan E. Ouma, Peter Ramharter, Michael Abdulla, Salim Aponte, John J. Massougbodji, Achille Briand, Valerie Mombo-Ngoma, Ghyslain Desai, Meghna Cot, Michel Nhacolo, Arsenio Sevene, Esperança Macete, Eusebio Menéndez, Clara Mayor, Alfredo Emerg Infect Dis Research Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004–2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space. Centers for Disease Control and Prevention 2019-10 /pmc/articles/PMC6759269/ /pubmed/31538557 http://dx.doi.org/10.3201/eid2510.181177 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Fonseca, Ana Maria
González, Raquel
Bardají, Azucena
Jairoce, Chenjerai
Rupérez, Maria
Jiménez, Alfons
Quintó, Llorenç
Cisteró, Pau
Vala, Anifa
Sacoor, Charfudin
Gupta, Himanshu
Hegewisch-Taylor, Jennifer
Brew, Joe
Ndam, Nicaise Tuikue
Kariuki, Simon
López, Marta
Dobaño, Carlota
Chitnis, Chetan E.
Ouma, Peter
Ramharter, Michael
Abdulla, Salim
Aponte, John J.
Massougbodji, Achille
Briand, Valerie
Mombo-Ngoma, Ghyslain
Desai, Meghna
Cot, Michel
Nhacolo, Arsenio
Sevene, Esperança
Macete, Eusebio
Menéndez, Clara
Mayor, Alfredo
VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
title VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
title_full VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
title_fullStr VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
title_full_unstemmed VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
title_short VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy
title_sort var2csa serology to detect plasmodium falciparum transmission patterns in pregnancy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759269/
https://www.ncbi.nlm.nih.gov/pubmed/31538557
http://dx.doi.org/10.3201/eid2510.181177
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