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Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas

PURPOSE: Evidence suggests a correlation of subventricular zone (SVZ) irradiation on survival. Most of the data have been analysed in glioblastoma patients. The aim of this study is to analyse the dose to the subventricular and periventricular zone and its outcomes in anaplastic gliomas. MATERIALS A...

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Autores principales: Valiyaveettil, Deepthi, Malik, Monica, Joseph, Deepa M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759320/
https://www.ncbi.nlm.nih.gov/pubmed/31645884
http://dx.doi.org/10.3332/ecancer.2019.956
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author Valiyaveettil, Deepthi
Malik, Monica
Joseph, Deepa M
author_facet Valiyaveettil, Deepthi
Malik, Monica
Joseph, Deepa M
author_sort Valiyaveettil, Deepthi
collection PubMed
description PURPOSE: Evidence suggests a correlation of subventricular zone (SVZ) irradiation on survival. Most of the data have been analysed in glioblastoma patients. The aim of this study is to analyse the dose to the subventricular and periventricular zone and its outcomes in anaplastic gliomas. MATERIALS AND METHODS: A retrospective analysis of patients with anaplastic gliomas were admitted for post-chemoradiation from January 2010 to June 2016 was done from treatment records. SVZ was contoured as 5 mm expansion along the lateral margin of the lateral ventricles, and PVZ was contoured as 5 mm lateral expansion adjacent to ventricles. Dosimetric data were collected from the treatment planning system. RESULTS: Ninety-five patients were included in the analysis. The median age was 35 years. Two- and five-year overall survival (OS) for the entire group was 84% and 54.2%, respectively. Two- and five-year progression-free survival (PFS) was 79.8% and 50.6%, respectively. Patients receiving <54 Gy to the i/l SVZ showed a significantly better PFS and OS. 5-Year OS was 72.6% in this group compared to 37% for the group receiving ≥54 Gy (p = 0.01). Five-year PFS was 69.9% in this group compared to 31.9% for the group receiving ≥54 Gy (p = 0.02). However, this was not significant in multivariate analysis. CONCLUSION: Increased dose to the ipsilateral SVZ does not correlate with improved survival in anaplastic gliomas. There is conflicting evidence regarding the benefit of irradiating the stem cell zones. Future studies should focus on optimizing doses to these areas to reduce detriment in neurocognition.
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spelling pubmed-67593202019-10-23 Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas Valiyaveettil, Deepthi Malik, Monica Joseph, Deepa M Ecancermedicalscience Research PURPOSE: Evidence suggests a correlation of subventricular zone (SVZ) irradiation on survival. Most of the data have been analysed in glioblastoma patients. The aim of this study is to analyse the dose to the subventricular and periventricular zone and its outcomes in anaplastic gliomas. MATERIALS AND METHODS: A retrospective analysis of patients with anaplastic gliomas were admitted for post-chemoradiation from January 2010 to June 2016 was done from treatment records. SVZ was contoured as 5 mm expansion along the lateral margin of the lateral ventricles, and PVZ was contoured as 5 mm lateral expansion adjacent to ventricles. Dosimetric data were collected from the treatment planning system. RESULTS: Ninety-five patients were included in the analysis. The median age was 35 years. Two- and five-year overall survival (OS) for the entire group was 84% and 54.2%, respectively. Two- and five-year progression-free survival (PFS) was 79.8% and 50.6%, respectively. Patients receiving <54 Gy to the i/l SVZ showed a significantly better PFS and OS. 5-Year OS was 72.6% in this group compared to 37% for the group receiving ≥54 Gy (p = 0.01). Five-year PFS was 69.9% in this group compared to 31.9% for the group receiving ≥54 Gy (p = 0.02). However, this was not significant in multivariate analysis. CONCLUSION: Increased dose to the ipsilateral SVZ does not correlate with improved survival in anaplastic gliomas. There is conflicting evidence regarding the benefit of irradiating the stem cell zones. Future studies should focus on optimizing doses to these areas to reduce detriment in neurocognition. Cancer Intelligence 2019-07-31 /pmc/articles/PMC6759320/ /pubmed/31645884 http://dx.doi.org/10.3332/ecancer.2019.956 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Valiyaveettil, Deepthi
Malik, Monica
Joseph, Deepa M
Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
title Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
title_full Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
title_fullStr Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
title_full_unstemmed Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
title_short Effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
title_sort effect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759320/
https://www.ncbi.nlm.nih.gov/pubmed/31645884
http://dx.doi.org/10.3332/ecancer.2019.956
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