Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca(2+) and ADP ribose (ADPR), an NAD(+)-metabolite produced under oxidative stress and neurodegenerative conditions, suggests a role in neurologic...

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Detalles Bibliográficos
Autores principales: Huang, Yihe, Roth, Becca, Lü, Wei, Du, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759353/
https://www.ncbi.nlm.nih.gov/pubmed/31513012
http://dx.doi.org/10.7554/eLife.50175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759353/
https://www.ncbi.nlm.nih.gov/pubmed/31513012
http://dx.doi.org/10.7554/eLife.50175

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