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Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18

In response to infection with intracellular microorganisms, old mice mobilize decreased numbers of antigen-specific CD8 T cells with reduced expression of effector molecules and impaired cytolytic activity. Molecular mechanisms behind these defects and the cell-intrinsic (affecting naïve CD8 T cells...

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Detalles Bibliográficos
Autores principales:	Jergović, Mladen, Thompson, Heather L., Renkema, Kristin R., Smithey, Megan J., Nikolich-Žugich, Janko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759569/ https://www.ncbi.nlm.nih.gov/pubmed/31620129 http://dx.doi.org/10.3389/fimmu.2019.02206

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