A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions

A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important bis-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a one-pot three-component reaction of 2-(2-formylphe...

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Autores principales: Shaabani, Shabnam, Shaabani, Ahmad, Kucerakova, Monika, Dusek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759581/
https://www.ncbi.nlm.nih.gov/pubmed/31620422
http://dx.doi.org/10.3389/fchem.2019.00623
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author Shaabani, Shabnam
Shaabani, Ahmad
Kucerakova, Monika
Dusek, Michal
author_facet Shaabani, Shabnam
Shaabani, Ahmad
Kucerakova, Monika
Dusek, Michal
author_sort Shaabani, Shabnam
collection PubMed
description A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important bis-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a one-pot three-component reaction of 2-(2-formylphenoxy) acetic acid and 2-aminobenzamide as bifunctional reagents and an isocyanide without using any catalyst, with excellent overall yields.
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spelling pubmed-67595812019-10-16 A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions Shaabani, Shabnam Shaabani, Ahmad Kucerakova, Monika Dusek, Michal Front Chem Chemistry A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important bis-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a one-pot three-component reaction of 2-(2-formylphenoxy) acetic acid and 2-aminobenzamide as bifunctional reagents and an isocyanide without using any catalyst, with excellent overall yields. Frontiers Media S.A. 2019-09-18 /pmc/articles/PMC6759581/ /pubmed/31620422 http://dx.doi.org/10.3389/fchem.2019.00623 Text en Copyright © 2019 Shaabani, Shaabani, Kucerakova and Dusek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Shaabani, Shabnam
Shaabani, Ahmad
Kucerakova, Monika
Dusek, Michal
A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions
title A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions
title_full A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions
title_fullStr A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions
title_full_unstemmed A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions
title_short A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions
title_sort one-pot synthesis of oxazepine-quinazolinone bis-heterocyclic scaffolds via isocyanide-based three-component reactions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759581/
https://www.ncbi.nlm.nih.gov/pubmed/31620422
http://dx.doi.org/10.3389/fchem.2019.00623
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