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Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility

Objective: Increased arterial pulsatility index (API), usually representative of distal vascular resistance, have been linked to cerebral small vessel disease. However, their relationship with cerebral microbleeds (CMBs) is less well-studied. The present study aimed to evaluate the relationship betw...

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Autores principales: Chou, Kun-Hsien, Wang, Pei-Ning, Peng, Li-Ning, Liu, Li-Kuo, Lee, Wei-Ju, Chen, Liang-Kung, Lin, Ching-Po, Chung, Chih-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759828/
https://www.ncbi.nlm.nih.gov/pubmed/31620078
http://dx.doi.org/10.3389/fneur.2019.01012
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author Chou, Kun-Hsien
Wang, Pei-Ning
Peng, Li-Ning
Liu, Li-Kuo
Lee, Wei-Ju
Chen, Liang-Kung
Lin, Ching-Po
Chung, Chih-Ping
author_facet Chou, Kun-Hsien
Wang, Pei-Ning
Peng, Li-Ning
Liu, Li-Kuo
Lee, Wei-Ju
Chen, Liang-Kung
Lin, Ching-Po
Chung, Chih-Ping
author_sort Chou, Kun-Hsien
collection PubMed
description Objective: Increased arterial pulsatility index (API), usually representative of distal vascular resistance, have been linked to cerebral small vessel disease. However, their relationship with cerebral microbleeds (CMBs) is less well-studied. The present study aimed to evaluate the relationship between CMBs and API. Methods: We cross-sectionally evaluated participants from a non-clinical stroke, non-demented community-based population. APIs of cervical internal carotid and vertebral arteries were measured by ultrasonography. CMBs were assessed by susceptibility-weighted-imaging on 3T magnetic resonance imaging (MRI). Subjects were classified according to CMB locations: deep/infratentorial (DI) or strictly lobar (SL) CMB groups. DI-CMB group also included subjects with simultaneous lobar CMBs. Results: Of the 681 subjects [62.2 (8.4) years, 43.5% men] included, CMBs were found in 92 (13.5%) subjects: 57 (8.4%) with DI-CMB and 35 (5.1%) with SL-CMB. The results showed that CMB location influenced their association with API. DI-CMB was significantly associated with elevated API of internal carotid arteries (β = 0.031; 95% confidence interval = 0.002–0.059; P = 0.03), while SL-CMB was significantly associated with elevated API of vertebral arteries (β = 0.050; 95% confidence interval = 0.006–0.094; P = 0.025) in multivariate analyses adjusting for age, sex, cardiovascular risk factors, white matter hyperintensities (WMH), and lacunes. Conclusion: Our study again emphasizes (1) the association between API and cerebral small vessel disease and (2) the pathogenic differences between DI- and SL-CMBs. Our results lead to the postulation that in the presence of CMBs without clinical dysfunction yet, insidious small vascular disorders might already occur with corresponding topography.
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spelling pubmed-67598282019-10-16 Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility Chou, Kun-Hsien Wang, Pei-Ning Peng, Li-Ning Liu, Li-Kuo Lee, Wei-Ju Chen, Liang-Kung Lin, Ching-Po Chung, Chih-Ping Front Neurol Neurology Objective: Increased arterial pulsatility index (API), usually representative of distal vascular resistance, have been linked to cerebral small vessel disease. However, their relationship with cerebral microbleeds (CMBs) is less well-studied. The present study aimed to evaluate the relationship between CMBs and API. Methods: We cross-sectionally evaluated participants from a non-clinical stroke, non-demented community-based population. APIs of cervical internal carotid and vertebral arteries were measured by ultrasonography. CMBs were assessed by susceptibility-weighted-imaging on 3T magnetic resonance imaging (MRI). Subjects were classified according to CMB locations: deep/infratentorial (DI) or strictly lobar (SL) CMB groups. DI-CMB group also included subjects with simultaneous lobar CMBs. Results: Of the 681 subjects [62.2 (8.4) years, 43.5% men] included, CMBs were found in 92 (13.5%) subjects: 57 (8.4%) with DI-CMB and 35 (5.1%) with SL-CMB. The results showed that CMB location influenced their association with API. DI-CMB was significantly associated with elevated API of internal carotid arteries (β = 0.031; 95% confidence interval = 0.002–0.059; P = 0.03), while SL-CMB was significantly associated with elevated API of vertebral arteries (β = 0.050; 95% confidence interval = 0.006–0.094; P = 0.025) in multivariate analyses adjusting for age, sex, cardiovascular risk factors, white matter hyperintensities (WMH), and lacunes. Conclusion: Our study again emphasizes (1) the association between API and cerebral small vessel disease and (2) the pathogenic differences between DI- and SL-CMBs. Our results lead to the postulation that in the presence of CMBs without clinical dysfunction yet, insidious small vascular disorders might already occur with corresponding topography. Frontiers Media S.A. 2019-09-18 /pmc/articles/PMC6759828/ /pubmed/31620078 http://dx.doi.org/10.3389/fneur.2019.01012 Text en Copyright © 2019 Chou, Wang, Peng, Liu, Lee, Chen, Lin and Chung. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Chou, Kun-Hsien
Wang, Pei-Ning
Peng, Li-Ning
Liu, Li-Kuo
Lee, Wei-Ju
Chen, Liang-Kung
Lin, Ching-Po
Chung, Chih-Ping
Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
title Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
title_full Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
title_fullStr Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
title_full_unstemmed Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
title_short Location-Specific Association Between Cerebral Microbleeds and Arterial Pulsatility
title_sort location-specific association between cerebral microbleeds and arterial pulsatility
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759828/
https://www.ncbi.nlm.nih.gov/pubmed/31620078
http://dx.doi.org/10.3389/fneur.2019.01012
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