Cargando…

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

BACKGROUND: α Carboxyl terminus 1 (αCT1) is a 25–amino acid therapeutic peptide incorporating the zonula occludens‐1 (ZO‐1)–binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on chronic wounds. In mice, we reported that αCT1 reduced arrhythmias after cardiac injury, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Jingbo, Hoagland, Daniel, Palatinus, Joseph A., He, Huamei, Iyyathurai, Jegan, Jourdan, L. Jane, Bultynck, Geert, Wang, Zhen, Zhang, Zhiwei, Schey, Kevin, Poelzing, Steven, McGowan, Francis X., Gourdie, Robert G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759879/ https://www.ncbi.nlm.nih.gov/pubmed/31422747 http://dx.doi.org/10.1161/JAHA.119.012385

Ejemplares similares

The role of the carboxyl terminus in folding of the serotonin transporter
por: El-Kasaby, Ali, et al.
Publicado: (2010)

Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus
por: Ek-Vitorín, José F., et al.
Publicado: (2018)

Connexins: substrates and regulators of autophagy
por: Iyyathurai, Jegan, et al.
Publicado: (2016)

An Escherichia coli strain for expression of the connexin45 carboxyl terminus attached to the 4th transmembrane domain
por: Kopanic, Jennifer L., et al.
Publicado: (2013)

Importance of the carboxyl terminus for folding and trafficking of the serotonin transporter
por: El-Kasaby, Ali, et al.
Publicado: (2009)

Analysis of Notch Lacking the Carboxyl Terminus Identified in Drosophila Embryos
por: Wesley, Cedric S., et al.
Publicado: (2000)

Gap junction assembly: roles for the formation plaque and regulation by the C-terminus of connexin43
por: Johnson, Ross G., et al.
Publicado: (2012)

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond
por: D'hondt, Catheleyne, et al.
Publicado: (2014)

Rab5(Q79L) interacts with the carboxyl terminus of RUFY3
por: Yoshida, Hitomi, et al.
Publicado: (2010)

Analysis of the Potential Role of GluA4 Carboxyl-Terminus in PDZ Interactions
por: Coleman, Sarah K., et al.
Publicado: (2010)

How does the carboxyl terminus assist folding and ER export of the serotonin transporter?
por: El-Kasaby, Ali, et al.
Publicado: (2012)

The carboxyl terminus of VEGF-A is a potential target for anti-angiogenic therapy
por: Carter, James G., et al.
Publicado: (2014)

The Carboxyl-Terminus of TRANSPARENT TESTA GLABRA1 Is Critical for Its Functions in Arabidopsis
por: Wang, Yating, et al.
Publicado: (2021)

Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor
por: Heng, Jie, et al.
Publicado: (2023)

Calmodulin Regulation of Na(V)1.4 Current: Role of Binding to the Carboxyl Terminus
por: Biswas, Subrata, et al.
Publicado: (2008)

The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry
por: Ayoub, Nabieh, et al.
Publicado: (2009)

Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
por: Moseng, Mitchell A., et al.
Publicado: (2022)

Connexin43 Carboxyl-Terminal Domain Directly Interacts with β-Catenin
por: Spagnol, Gaelle, et al.
Publicado: (2018)

Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1
por: Rhett, J. Matthew, et al.
Publicado: (2011)

Phosphorylation-Dependent Intra-Domain Interaction of the Cx37 Carboxyl-Terminus Controls Cell Survival
por: Jacobsen, Nicole L., et al.
Publicado: (2019)

A Conserved Tyrosine Residue in Slitrk3 Carboxyl-Terminus Is Critical for GABAergic Synapse Development
por: Li, Jun, et al.
Publicado: (2019)

Diacidic Motifs in the Carboxyl Terminus Are Required for ER Exit and Translocation to the Plasma Membrane of NKCC2
por: Bakhos-Douaihy, Dalal, et al.
Publicado: (2022)

Connexin 43 C‐terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein–protein interactions in glioblastoma
por: Kuang, Jing‐Ya, et al.
Publicado: (2018)

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions
por: Allsopp, Rebecca C., et al.
Publicado: (2013)

The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells
Publicado: (1992)

Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production
por: Pan, Yen-Yu, et al.
Publicado: (2012)

Absence of PTHrP Nuclear Localization and Carboxyl Terminus Sequences Leads to Abnormal Brain Development and Function
por: Gu, Zhen, et al.
Publicado: (2012)

Role of Cysteine Residues in the Carboxyl-Terminus of the Follicle-Stimulating Hormone Receptor in Intracellular Traffic and Postendocytic Processing
por: Melo-Nava, Brenda, et al.
Publicado: (2016)

Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70‐interacting protein in postmenopausal breast cancer
por: Kurozumi, Sasagu, et al.
Publicado: (2016)

The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function
por: Lu, Mei-Yi, et al.
Publicado: (2018)

Response to Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”
por: Moseng, Mitchell A., et al.
Publicado: (2023)

Technical Comment on “Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling”
por: Flygaard, Rasmus Kock, et al.
Publicado: (2023)

Connexin 43 overexpression induces lung cancer angiogenesis in vitro following phosphorylation at Ser279 in its C-terminus
por: Zhou, Zizi, et al.
Publicado: (2022)

Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer
por: Patani, Neill, et al.
Publicado: (2010)

Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma
por: LIANG, ZHE LONG, et al.
Publicado: (2013)

Carboxyl Terminus of Hsp70-Interacting Protein Is Increased in Serum and Cerebrospinal Fluid of Patients With Spinocerebellar Ataxia Type 3
por: Hu, Zheng-wei, et al.
Publicado: (2019)

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability
por: Stout, Randy F., et al.
Publicado: (2017)

The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K(+) Current Amplitudes by Controlling Channel Trafficking
por: Choveau, Frank S., et al.
Publicado: (2015)

Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein
por: Wang, Lei, et al.
Publicado: (2016)

Snapin Specifically Up-Regulates Ca(v)1.3 Ca(2+) Channel Variant with a Long Carboxyl Terminus
por: Jeong, Sua, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mpm6i1646t8165srbkd5c4am2g