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Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life

BACKGROUND: Cardiovascular disease (CVD) and fatigue commonly co‐occur in older adults, yet the subjective nature of fatigue and its situational dependence leave the true magnitude of this association undefined. METHODS AND RESULTS: Six‐hundred and twenty‐five participants with no history of CVD (ag...

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Autores principales: Qiao, Yujia, Martinez‐Amezcua, Pablo, Wanigatunga, Amal A., Urbanek, Jacek K., Simonsick, Eleanor M., Ferrucci, Luigi, Schrack, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759892/
https://www.ncbi.nlm.nih.gov/pubmed/31409206
http://dx.doi.org/10.1161/JAHA.119.013049
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author Qiao, Yujia
Martinez‐Amezcua, Pablo
Wanigatunga, Amal A.
Urbanek, Jacek K.
Simonsick, Eleanor M.
Ferrucci, Luigi
Schrack, Jennifer A.
author_facet Qiao, Yujia
Martinez‐Amezcua, Pablo
Wanigatunga, Amal A.
Urbanek, Jacek K.
Simonsick, Eleanor M.
Ferrucci, Luigi
Schrack, Jennifer A.
author_sort Qiao, Yujia
collection PubMed
description BACKGROUND: Cardiovascular disease (CVD) and fatigue commonly co‐occur in older adults, yet the subjective nature of fatigue and its situational dependence leave the true magnitude of this association undefined. METHODS AND RESULTS: Six‐hundred and twenty‐five participants with no history of CVD (aged 68.1+12.0 years), from the Baltimore Longitudinal Study of Aging who underwent ≥2 clinic visits between 2007 and 2015 were classified according to sex‐specific predicted 10‐year CVD risk scores using the Framingham CVD risk score (Framingham) and the Pooled Cohort Equation at baseline. Perceived fatigability was assessed using the Borg rating of perceived exertion scale after a 5‐minute treadmill walk (0.67 m/s, 0% grade). Linear models were used to assess the association between baseline CVD risk and perceived fatigability an average of 4.5 years later, adjusted for demographics, behaviors, and medical history. In final models, a 5% higher baseline Pooled Cohort Equation score was associated with greater perceived fatigability at follow‐up (β=0.13 rating of perceived exertion, P=0.008). Stratified analyses suggested this association was stronger among those aged ≤70 years and those with obesity. Of the individual CVD risk score components, older age was most strongly associated with perceived fatigability (β=0.48, P<0.001), followed by women (β=0.11, P=0.002), and treated hypertension (β=0.11, P=0.003). There was no association with the Framingham risk score. CONCLUSIONS: Perceived fatigability was higher among participants with greater CVD risk measured using the Pooled Cohort Equation risk score. The strong associations with hypertension and obesity suggest prevention and promotion of cardiovascular health may also lower perceived fatigability, particularly among those aged ≤70 years or living with obesity.
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spelling pubmed-67598922019-09-30 Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life Qiao, Yujia Martinez‐Amezcua, Pablo Wanigatunga, Amal A. Urbanek, Jacek K. Simonsick, Eleanor M. Ferrucci, Luigi Schrack, Jennifer A. J Am Heart Assoc Original Research BACKGROUND: Cardiovascular disease (CVD) and fatigue commonly co‐occur in older adults, yet the subjective nature of fatigue and its situational dependence leave the true magnitude of this association undefined. METHODS AND RESULTS: Six‐hundred and twenty‐five participants with no history of CVD (aged 68.1+12.0 years), from the Baltimore Longitudinal Study of Aging who underwent ≥2 clinic visits between 2007 and 2015 were classified according to sex‐specific predicted 10‐year CVD risk scores using the Framingham CVD risk score (Framingham) and the Pooled Cohort Equation at baseline. Perceived fatigability was assessed using the Borg rating of perceived exertion scale after a 5‐minute treadmill walk (0.67 m/s, 0% grade). Linear models were used to assess the association between baseline CVD risk and perceived fatigability an average of 4.5 years later, adjusted for demographics, behaviors, and medical history. In final models, a 5% higher baseline Pooled Cohort Equation score was associated with greater perceived fatigability at follow‐up (β=0.13 rating of perceived exertion, P=0.008). Stratified analyses suggested this association was stronger among those aged ≤70 years and those with obesity. Of the individual CVD risk score components, older age was most strongly associated with perceived fatigability (β=0.48, P<0.001), followed by women (β=0.11, P=0.002), and treated hypertension (β=0.11, P=0.003). There was no association with the Framingham risk score. CONCLUSIONS: Perceived fatigability was higher among participants with greater CVD risk measured using the Pooled Cohort Equation risk score. The strong associations with hypertension and obesity suggest prevention and promotion of cardiovascular health may also lower perceived fatigability, particularly among those aged ≤70 years or living with obesity. John Wiley and Sons Inc. 2019-08-14 /pmc/articles/PMC6759892/ /pubmed/31409206 http://dx.doi.org/10.1161/JAHA.119.013049 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Qiao, Yujia
Martinez‐Amezcua, Pablo
Wanigatunga, Amal A.
Urbanek, Jacek K.
Simonsick, Eleanor M.
Ferrucci, Luigi
Schrack, Jennifer A.
Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life
title Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life
title_full Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life
title_fullStr Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life
title_full_unstemmed Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life
title_short Association Between Cardiovascular Risk and Perceived Fatigability in Mid‐to‐Late Life
title_sort association between cardiovascular risk and perceived fatigability in mid‐to‐late life
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759892/
https://www.ncbi.nlm.nih.gov/pubmed/31409206
http://dx.doi.org/10.1161/JAHA.119.013049
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