Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors

Secondary metabolites from natural products are a potential source of acetylcholinesterase inhibitors (AChEIs), which is a key enzyme in the treatment of many neurodegenerative diseases. Inspired by the reported activities of isoquinoline-derivative alkaloids herein we report the design, one step sy...

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Detalles Bibliográficos
Autores principales: de Lima, Bruna R., Lima, Juliana M., Maciel, Jéssica B., Valentim, Carolina Q., Nunomura, Rita de Cássia S., Lima, Emerson S., Koolen, Hector H. F., de Souza, Afonso Duarte L, Pinheiro, Maria Lúcia B., Cass, Quezia B., da Silva, Felipe Moura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760013/
https://www.ncbi.nlm.nih.gov/pubmed/31620424
http://dx.doi.org/10.3389/fchem.2019.00629

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