Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran

OBJECTIVES: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 ge...

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Autores principales: Moghimi, Mansour, Tavakoli, Forough, Doosti, Masoud, Ahmadi-Vasmehjani, Abbas, Akhondi-Meybodi, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760063/
https://www.ncbi.nlm.nih.gov/pubmed/31551080
http://dx.doi.org/10.1186/s13104-019-4651-z
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author Moghimi, Mansour
Tavakoli, Forough
Doosti, Masoud
Ahmadi-Vasmehjani, Abbas
Akhondi-Meybodi, Mohsen
author_facet Moghimi, Mansour
Tavakoli, Forough
Doosti, Masoud
Ahmadi-Vasmehjani, Abbas
Akhondi-Meybodi, Mohsen
author_sort Moghimi, Mansour
collection PubMed
description OBJECTIVES: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. RESULT: The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003).
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spelling pubmed-67600632019-09-30 Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran Moghimi, Mansour Tavakoli, Forough Doosti, Masoud Ahmadi-Vasmehjani, Abbas Akhondi-Meybodi, Mohsen BMC Res Notes Research Note OBJECTIVES: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. RESULT: The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003). BioMed Central 2019-09-24 /pmc/articles/PMC6760063/ /pubmed/31551080 http://dx.doi.org/10.1186/s13104-019-4651-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Moghimi, Mansour
Tavakoli, Forough
Doosti, Masoud
Ahmadi-Vasmehjani, Abbas
Akhondi-Meybodi, Mohsen
Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
title Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
title_full Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
title_fullStr Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
title_full_unstemmed Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
title_short Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
title_sort correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among hcv patients in yazd, iran
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760063/
https://www.ncbi.nlm.nih.gov/pubmed/31551080
http://dx.doi.org/10.1186/s13104-019-4651-z
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