Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer’s disease

Circadian rhythm disruption is one of the earliest biomarkers of Alzheimer’s disease (AD), and there exists a bidirectional relationship by which dysfunctions in the circadian clock drive AD pathology and AD pathology drives circadian dysfunction. Casein kinase 1 (CK1) isoforms ε and δ, key circadia...

Descripción completa

Detalles Bibliográficos
Autores principales: Sundaram, S., Nagaraj, S., Mahoney, H., Portugues, A., Li, W., Millsaps, K., Faulkner, J., Yunus, A., Burns, C., Bloom, C., Said, M., Pinto, L., Azam, S., Flores, M., Henriksen, A., Gamsby, J., Gulick, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760153/
https://www.ncbi.nlm.nih.gov/pubmed/31551449
http://dx.doi.org/10.1038/s41598-019-50197-x

Ejemplares similares

Ejemplares similares