The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation

Gliomas aberrantly express programmed cell death ligand-1 (PD-L1), which has a pivotal role in immunoevasion. The splicing isoform of FKBP5, termed FKBP51s, is a PD-L1 foldase, assisting the immune checkpoint molecule in maturation and expression on the plasma membrane. The concept that PD-L1 suppor...

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Detalles Bibliográficos
Autores principales: D’Arrigo, Paolo, Digregorio, Marina, Romano, Simona, Tufano, Martina, Rea, Anna, Hausch, Felix, Dedobbeleer, Matthias, Vigorito, Vincenza, Russo, Salvatore, Bauder, Michael, Rogister, Bernard, Romano, Maria Fiammetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760221/
https://www.ncbi.nlm.nih.gov/pubmed/31583120
http://dx.doi.org/10.1038/s41420-019-0216-0

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