Cargando…

The DRS–AIMP2–EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex

Aminoacyl-tRNA synthetases (ARSs) play essential roles in protein biosynthesis as well as in other cellular processes, often using evolutionarily acquired domains. For possible cooperativity and synergistic effects, nine ARSs assemble into the multi-tRNA synthetase complex (MSC) with three scaffold...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hahn, Hyunggu, Park, Sang Ho, Kim, Hyun-Jung, Kim, Sunghoon, Han, Byung Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2019
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760448/ https://www.ncbi.nlm.nih.gov/pubmed/31576228 http://dx.doi.org/10.1107/S2052252519010790

Ejemplares similares

Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex
por: Kim, Kyung Rok, et al.
Publicado: (2013)

Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves
por: Kim, Muwoong, et al.
Publicado: (2019)

Case Report: Mutation in AIMP2/P38, the Scaffold for the Multi-Trna Synthetase Complex, and Association With Progressive Neurodevelopmental Disorders
por: Mazaheri, Mahta, et al.
Publicado: (2022)

Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes
por: Kim, Dong Kyu, et al.
Publicado: (2021)

HIV-1 Gag Binds the Multi-Aminoacyl-tRNA Synthetase Complex via the EPRS Subunit
por: Jin, Danni, et al.
Publicado: (2023)

Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases
por: Lee, Eun-Young, et al.
Publicado: (2018)

VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2
por: Yun, Seung Pil, et al.
Publicado: (2017)

AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice
por: Kim, Doyeun, et al.
Publicado: (2018)

Functional and pathologic association of aminoacyl-tRNA synthetases with cancer
por: Sung, Yulseung, et al.
Publicado: (2022)

Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis
por: Khan, Krishnendu, et al.
Publicado: (2022)

Exosomal secretion of truncated cytosolic lysyl-tRNA synthetase induces inflammation during cell starvation
por: Kim, Sang Bum, et al.
Publicado: (2018)

Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2
por: Kim, Dae Gyu, et al.
Publicado: (2020)

Nucleolar Localization of Human Methionyl–Trna Synthetase and Its Role in Ribosomal RNA Synthesis
por: Ko, Young-Gyu, et al.
Publicado: (2000)

Data on optimization of expression and purification of AIMP2-DX2 protein in Escherichia coli
por: Jha, Roshan, et al.
Publicado: (2017)

Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma
por: Kim, Yong-Wan, et al.
Publicado: (2012)

AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells
por: Kim, Sun Mi, et al.
Publicado: (2018)

Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation to protect cells against oxidative stress
por: Lee, Jin Young, et al.
Publicado: (2014)

HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy
por: Kim, Chul, et al.
Publicado: (2019)

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis
por: Kim, Dae Gyu, et al.
Publicado: (2022)

An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody
por: Kim, Dae Gyu, et al.
Publicado: (2020)

Plasma Lysyl-tRNA Synthetase 1 (KARS1) as a Novel Diagnostic and Monitoring Biomarker for Colorectal Cancer
por: Suh, Ji Hun, et al.
Publicado: (2020)

Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer
por: Ku, Jayoung, et al.
Publicado: (2020)

A threonyl-tRNA synthetase-mediated translation initiation machinery
por: Jeong, Seung Jae, et al.
Publicado: (2019)

Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity
por: Rathnayake, Udumbara M., et al.
Publicado: (2019)

AIMp1 Potentiates T(H)1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity
por: Liang, Dan, et al.
Publicado: (2018)

Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants
por: Kim, Sulhee, et al.
Publicado: (2021)

Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry
por: Tao, Yeqing, et al.
Publicado: (2017)

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase
por: Fang, Pengfei, et al.
Publicado: (2015)

Aminoacyl-tRNA synthetases
por: Rubio Gomez, Miguel Angel, et al.
Publicado: (2020)

Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis
por: Choi, Jin Woo, et al.
Publicado: (2011)

Expanding a tyrosyl-tRNA synthetase assay to other aminoacyl-tRNA synthetases
por: Richardson, Charles J., et al.
Publicado: (2015)

Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer
por: Jung, Ji Ye, et al.
Publicado: (2017)

Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
por: Lee, Ji-Hyun, et al.
Publicado: (2015)

Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug
por: Lee, BoRa, et al.
Publicado: (2022)

Degradation of AIMP1/p43 Induced by Hepatitis C Virus E2 Leads to Upregulation of TGF-β Signaling and Increase in Surface Expression of gp96
por: Kim, Min Soo, et al.
Publicado: (2014)

Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond
por: Galindo-Feria, Angeles S., et al.
Publicado: (2022)

Extracellular vesicles derived from macrophages display glycyl‐tRNA synthetase 1 and exhibit anti‐cancer activity
por: Goughnour, Peter C., et al.
Publicado: (2020)

Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1
por: Cho, Seongmin, et al.
Publicado: (2020)

Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells
por: Kim, Sang Bum, et al.
Publicado: (2017)

3-Dimensional architecture of the human multi-tRNA synthetase complex
por: Khan, Krishnendu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_18d91gjrjcspihssicku3v1srq