Cargando…

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

BACKGROUND: The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, ps...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamilton, Olivia K. L., Zhang, Qian, McRae, Allan F., Walker, Rosie M., Morris, Stewart W., Redmond, Paul, Campbell, Archie, Murray, Alison D., Porteous, David J., Evans, Kathryn L., McIntosh, Andrew M., Deary, Ian J., Marioni, Riccardo E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760607/ https://www.ncbi.nlm.nih.gov/pubmed/30842548 http://dx.doi.org/10.1038/s41366-018-0262-3

Ejemplares similares

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
por: Marioni, Riccardo E, et al.
Publicado: (2015)

DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
por: Seeboth, Anne, et al.
Publicado: (2020)

DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936
por: Gale, Catharine R., et al.
Publicado: (2018)

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
por: Hillary, Robert F., et al.
Publicado: (2019)

The epigenetic clock and objectively measured sedentary and walking behavior in older adults: the Lothian Birth Cohort 1936
por: Gale, Catharine R., et al.
Publicado: (2018)

Attitudes to ageing, biomarkers of ageing and mortality: the Lothian Birth Cohort 1936
por: McLachlan, Kyle J J, et al.
Publicado: (2020)

Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936
por: Iveson, Matthew H., et al.
Publicado: (2022)

Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design
por: Hillary, Robert F., et al.
Publicado: (2022)

Epigenetic prediction of complex traits and death
por: McCartney, Daniel L., et al.
Publicado: (2018)

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability
por: Stevenson, Anna J., et al.
Publicado: (2020)

Bayesian reassessment of the epigenetic architecture of complex traits
por: Trejo Banos, Daniel, et al.
Publicado: (2020)

The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer’s disease
por: A Gadd, Danni, et al.
Publicado: (2022)

Birth weight associations with DNA methylation differences in an adult population
por: Madden, Rebecca A., et al.
Publicado: (2020)

Author Correction: Bayesian reassessment of the epigenetic architecture of complex traits
por: Banos, Daniel Trejo, et al.
Publicado: (2020)

Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936
por: Hamilton, Gillian, et al.
Publicado: (2011)

Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936
por: Corley, Janie, et al.
Publicado: (2019)

Epigenetic signatures of starting and stopping smoking
por: McCartney, Daniel L., et al.
Publicado: (2018)

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
por: Hillary, Robert F., et al.
Publicado: (2020)

Epigenetic prediction of major depressive disorder
por: Barbu, Miruna C., et al.
Publicado: (2020)

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing
por: Stevenson, Anna J., et al.
Publicado: (2018)

DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health
por: Mur, Jure, et al.
Publicado: (2020)

Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936
por: Taylor, Adele M, et al.
Publicado: (2018)

DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921
por: Sibbett, Ruth A., et al.
Publicado: (2020)

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD
por: Bermingham, Mairead L., et al.
Publicado: (2019)

Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921
por: Harris, Sarah E., et al.
Publicado: (2016)

Associations Between Declining Physical and Cognitive Functions in the Lothian Birth Cohort 1936
por: Okely, Judith A, et al.
Publicado: (2020)

Longitudinal Associations Between Loneliness and Cognitive Ability in the Lothian Birth Cohort 1936
por: Okely, Judith A, et al.
Publicado: (2019)

Profiles of physical, emotional and psychosocial wellbeing in the Lothian birth cohort 1936
por: Zammit, Andrea R, et al.
Publicado: (2012)

Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936
por: Corley, Janie, et al.
Publicado: (2015)

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life
por: Stevenson, Anna J., et al.
Publicado: (2019)

Epigenetic scores for the circulating proteome as tools for disease prediction
por: Gadd, Danni A, et al.
Publicado: (2022)

Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6
por: Stevenson, Anna J, et al.
Publicado: (2021)

Retinal microvascular features and cognitive change in the Lothian-Birth Cohort 1936
por: McGrory, Sarah, et al.
Publicado: (2019)

Correction: Epigenetic scores for the circulating proteome as tools for disease prediction
por: Gadd, Danni A, et al.
Publicado: (2023)

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease
por: McCartney, Daniel L., et al.
Publicado: (2018)

Patterns and associates of cognitive function, psychosocial wellbeing and health in the Lothian Birth Cohort 1936
por: Zammit, Andrea R, et al.
Publicado: (2014)

Physical frailty and decline in general and specific cognitive abilities: the Lothian Birth Cohort 1936
por: Gale, Catharine, et al.
Publicado: (2020)

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936
por: Hamilton, O. K. L., et al.
Publicado: (2021)

Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936
por: Harris, Sarah E., et al.
Publicado: (2017)

An epigenome-wide association study of sex-specific chronological ageing
por: McCartney, Daniel L., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_06b74qst0e0mm93o8sg9irs8dt