Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology

Amplification and overexpression of MDM2 and CDK4 are well-known diagnostic criteria for well-differentiated liposarcoma (WDLPS)/dedifferentiated liposarcoma (DDLPS). Although it was reported that the depletion of MDM2 or CDK4 decreased proliferation in DDLPS cell lines, whether MDM2 and CDK4 induce...

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Detalles Bibliográficos
Autores principales: Kim, Yu Jin, Kim, Mingi, Park, Hyung Kyu, Yu, Dan Bi, Jung, Kyungsoo, Song, Kyoung, Choi, Yoon-La
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760642/
https://www.ncbi.nlm.nih.gov/pubmed/31160689
http://dx.doi.org/10.1038/s41374-019-0263-4

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