Cargando…

Prenatal Exposure to Environmentally-Relevant Contaminants Perturbs Male Reproductive Parameters Across Multiple Generations that are Partially Protected by Folic Acid Supplementation

The paternal environment is thought to influence sperm quality and future progeny may also be impacted. We hypothesized that prenatal exposure to environmentally-relevant contaminants impairs male reproduction, altering embryo gene expression over multiple generations. Folic acid (FA) can improve sp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lessard, Maryse, Herst, Pauline M., Charest, Phanie L., Navarro, Pauline, Joly-Beauparlant, Charles, Droit, Arnaud, Kimmins, Sarah, Trasler, Jacquetta, Benoit-Biancamano, Marie-Odile, MacFarlane, Amanda J., Dalvai, Mathieu, Bailey, Janice L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761122/ https://www.ncbi.nlm.nih.gov/pubmed/31554827 http://dx.doi.org/10.1038/s41598-019-50060-z

Ejemplares similares

Exposure to environmental contaminants and folic acid supplementation intergenerationally impact fetal skeleton development through the paternal lineage in a rat model
por: L. Charest, Phanie, et al.
Publicado: (2022)

Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced by in utero environmental contaminant exposure
por: Herst, P M, et al.
Publicado: (2019)

Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage
por: Maurice, Clotilde, et al.
Publicado: (2021)

Protective and sex‐specific effects of moderate dose folic acid supplementation on the placenta following assisted reproduction in mice
por: Ihirwe, Rita Gloria, et al.
Publicado: (2022)

DIA proteomics data from a UPS1-spiked E.coli protein mixture processed with six software tools
por: Gotti, Clarisse, et al.
Publicado: (2022)

Medically assisted reproduction and the risk of being born small and very small for gestational age: Assessing prematurity status as an effect modifier
por: Gorgui, Jessica, et al.
Publicado: (2022)

Inferring and modeling inheritance of differentially methylated changes across multiple generations
por: Belleau, Pascal, et al.
Publicado: (2018)

Inferring and modeling inheritance of differentially methylated changes across multiple generations
por: Belleau, Pascal, et al.
Publicado: (2018)

Critical Period of Nonpromoter DNA Methylation Acquisition during Prenatal Male Germ Cell Development
por: Niles, Kirsten M., et al.
Publicado: (2011)

Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines
por: Lamers, Yvonne, et al.
Publicado: (2018)

Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia
por: Mangnier, Loïc, et al.
Publicado: (2022)

RNA sequencing data of human prostate cancer cells treated with androgens
por: Poluri, Raghavendra Tejo Karthik, et al.
Publicado: (2019)

Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children
por: Oulhote, Youssef, et al.
Publicado: (2020)

Special section on honey bee health and disease
por: Benoit-Biancamano, Marie-Odile
Publicado: (2023)

Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size
por: Meredith, Megan, et al.
Publicado: (2016)

Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns
por: Ly, Lundi, et al.
Publicado: (2020)

Anaphylaxis associated with folic acid: domestic case review
por: Kerr, Pauline E, et al.
Publicado: (2014)

HCK and ABAA: A Newly Designed Pipeline to Improve Fungi Metabarcoding Analysis
por: Mlaga, Kodjovi D., et al.
Publicado: (2021)

Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism
por: Chan, Donovan, et al.
Publicado: (2019)

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females
por: McGraw, Serge, et al.
Publicado: (2013)

metagene Profiles Analyses Reveal Regulatory Element’s Factor-Specific Recruitment Patterns
por: Joly Beauparlant, Charles, et al.
Publicado: (2016)

Transcriptional signature of lymphoblastoid cell lines of BRCA1, BRCA2 and non-BRCA1/2 high risk breast cancer families
por: Pouliot, Marie-Christine, et al.
Publicado: (2017)

The impact of direct provision accommodation for asylum seekers on organisation and delivery of local primary care and social care services: A case study
por: Pieper, Hans-Olaf, et al.
Publicado: (2011)

Coordinate regulation of DNA methyltransferase expression during oogenesis
por: Lucifero, Diana, et al.
Publicado: (2007)

Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein
por: Aumailley, Lucie, et al.
Publicado: (2018)

Histology of the whole body of honey bees: tissue fixation and processing
por: Lussier, Joanie, et al.
Publicado: (2023)

Faulty Folic Acid Assumptions: Prenatal Supplements Not Always a Good Idea
por: Hood, Ernie
Publicado: (2006)

Social Inequalities in Prenatal Folic Acid Supplementation: Results from the ELFE Cohort
por: Camier, Aurore, et al.
Publicado: (2019)

Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment
por: Lafleur, Sarah, et al.
Publicado: (2023)

Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L
por: La Salle, Sophie, et al.
Publicado: (2007)

Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations
por: Karahan, Gurbet, et al.
Publicado: (2021)

Effect of folic acid in prenatal alcohol induced behavioral impairment in Swiss albino mice
por: Shrestha, Uttam, et al.
Publicado: (2013)

Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder
por: Schmidt, Rebecca J., et al.
Publicado: (2017)

FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells
por: Fournier, Michèle, et al.
Publicado: (2016)

Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh
por: Kancherla, Vijaya, et al.
Publicado: (2017)

Morphological Evaluation of Transscleral Laser Retinopexy in Rabbits: Comparison of Optical Coherence Tomography and Histologic Examinations
por: Vanore, Maria, et al.
Publicado: (2023)

Joint Effects of Prenatal Folic Acid Supplement with Prenatal Multivitamin and Iron Supplement on Obesity in Preschoolers Born SGA: Sex Specific Difference
por: Lu, Qing, et al.
Publicado: (2023)

Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer
por: Chan, Donovan, et al.
Publicado: (2023)

Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study
por: Shen, Minxue, et al.
Publicado: (2016)

Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques
por: Clain, Julien A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_71cs1ddqknnemf2jvui0gto3ps