Purified F-ATP synthase forms a Ca(2+)-dependent high-conductance channel matching the mitochondrial permeability transition pore

The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca(2+) dissipates the H(+) gradient generated...

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Detalles Bibliográficos
Autores principales: Urbani, Andrea, Giorgio, Valentina, Carrer, Andrea, Franchin, Cinzia, Arrigoni, Giorgio, Jiko, Chimari, Abe, Kazuhiro, Maeda, Shintaro, Shinzawa-Itoh, Kyoko, Bogers, Janna F. M., McMillan, Duncan G. G., Gerle, Christoph, Szabò, Ildikò, Bernardi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761146/
https://www.ncbi.nlm.nih.gov/pubmed/31554800
http://dx.doi.org/10.1038/s41467-019-12331-1

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