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R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. Here, we explore the dynamics of Wnt signaling in the colon. We identify two populations of cells with...

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Detalles Bibliográficos
Autores principales:	Harnack, Christine, Berger, Hilmar, Antanaviciute, Agne, Vidal, Ramon, Sauer, Sascha, Simmons, Alison, Meyer, Thomas F., Sigal, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761174/ https://www.ncbi.nlm.nih.gov/pubmed/31554819 http://dx.doi.org/10.1038/s41467-019-12349-5

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