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Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance
The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761279/ https://www.ncbi.nlm.nih.gov/pubmed/31607948 http://dx.doi.org/10.3389/fphys.2019.01205 |
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author | Lu, Xia Jin, Guantao Chen, Wenjin Yu, Xinguang Ling, Feng |
author_facet | Lu, Xia Jin, Guantao Chen, Wenjin Yu, Xinguang Ling, Feng |
author_sort | Lu, Xia |
collection | PubMed |
description | The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS. |
format | Online Article Text |
id | pubmed-6761279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67612792019-10-13 Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance Lu, Xia Jin, Guantao Chen, Wenjin Yu, Xinguang Ling, Feng Front Physiol Physiology The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS. Frontiers Media S.A. 2019-09-19 /pmc/articles/PMC6761279/ /pubmed/31607948 http://dx.doi.org/10.3389/fphys.2019.01205 Text en Copyright © 2019 Lu, Jin, Chen, Yu and Ling. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Lu, Xia Jin, Guantao Chen, Wenjin Yu, Xinguang Ling, Feng Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance |
title | Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance |
title_full | Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance |
title_fullStr | Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance |
title_full_unstemmed | Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance |
title_short | Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance |
title_sort | depiction of physiological homeostasis by self-coupled system and its significance |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761279/ https://www.ncbi.nlm.nih.gov/pubmed/31607948 http://dx.doi.org/10.3389/fphys.2019.01205 |
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