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Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease

A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was...

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Autores principales: Fujimoto, Shino, Sakai, Tomoyuki, Kawabata, Hiroshi, Kurose, Nozomu, Yamada, Sohsuke, Doai, Mariko, Matoba, Munetaka, Iwao-Kawanami, Haruka, Kawanami, Takafumi, Mizuta, Shuichi, Fukushima, Toshihiro, Mizumaki, Hiroki, Yamaguchi, Masaki, Masaki, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761330/
https://www.ncbi.nlm.nih.gov/pubmed/31178507
http://dx.doi.org/10.2169/internalmedicine.2738-19
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author Fujimoto, Shino
Sakai, Tomoyuki
Kawabata, Hiroshi
Kurose, Nozomu
Yamada, Sohsuke
Doai, Mariko
Matoba, Munetaka
Iwao-Kawanami, Haruka
Kawanami, Takafumi
Mizuta, Shuichi
Fukushima, Toshihiro
Mizumaki, Hiroki
Yamaguchi, Masaki
Masaki, Yasufumi
author_facet Fujimoto, Shino
Sakai, Tomoyuki
Kawabata, Hiroshi
Kurose, Nozomu
Yamada, Sohsuke
Doai, Mariko
Matoba, Munetaka
Iwao-Kawanami, Haruka
Kawanami, Takafumi
Mizuta, Shuichi
Fukushima, Toshihiro
Mizumaki, Hiroki
Yamaguchi, Masaki
Masaki, Yasufumi
author_sort Fujimoto, Shino
collection PubMed
description A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis.
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spelling pubmed-67613302019-09-27 Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease Fujimoto, Shino Sakai, Tomoyuki Kawabata, Hiroshi Kurose, Nozomu Yamada, Sohsuke Doai, Mariko Matoba, Munetaka Iwao-Kawanami, Haruka Kawanami, Takafumi Mizuta, Shuichi Fukushima, Toshihiro Mizumaki, Hiroki Yamaguchi, Masaki Masaki, Yasufumi Intern Med Case Report A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis. The Japanese Society of Internal Medicine 2019-06-07 2019-09-01 /pmc/articles/PMC6761330/ /pubmed/31178507 http://dx.doi.org/10.2169/internalmedicine.2738-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Fujimoto, Shino
Sakai, Tomoyuki
Kawabata, Hiroshi
Kurose, Nozomu
Yamada, Sohsuke
Doai, Mariko
Matoba, Munetaka
Iwao-Kawanami, Haruka
Kawanami, Takafumi
Mizuta, Shuichi
Fukushima, Toshihiro
Mizumaki, Hiroki
Yamaguchi, Masaki
Masaki, Yasufumi
Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
title Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
title_full Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
title_fullStr Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
title_full_unstemmed Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
title_short Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
title_sort osteosarcoma manifesting systemic inflammation and histological features mimicking plasma cell-type castleman disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761330/
https://www.ncbi.nlm.nih.gov/pubmed/31178507
http://dx.doi.org/10.2169/internalmedicine.2738-19
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