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Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease
A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761330/ https://www.ncbi.nlm.nih.gov/pubmed/31178507 http://dx.doi.org/10.2169/internalmedicine.2738-19 |
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author | Fujimoto, Shino Sakai, Tomoyuki Kawabata, Hiroshi Kurose, Nozomu Yamada, Sohsuke Doai, Mariko Matoba, Munetaka Iwao-Kawanami, Haruka Kawanami, Takafumi Mizuta, Shuichi Fukushima, Toshihiro Mizumaki, Hiroki Yamaguchi, Masaki Masaki, Yasufumi |
author_facet | Fujimoto, Shino Sakai, Tomoyuki Kawabata, Hiroshi Kurose, Nozomu Yamada, Sohsuke Doai, Mariko Matoba, Munetaka Iwao-Kawanami, Haruka Kawanami, Takafumi Mizuta, Shuichi Fukushima, Toshihiro Mizumaki, Hiroki Yamaguchi, Masaki Masaki, Yasufumi |
author_sort | Fujimoto, Shino |
collection | PubMed |
description | A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis. |
format | Online Article Text |
id | pubmed-6761330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-67613302019-09-27 Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease Fujimoto, Shino Sakai, Tomoyuki Kawabata, Hiroshi Kurose, Nozomu Yamada, Sohsuke Doai, Mariko Matoba, Munetaka Iwao-Kawanami, Haruka Kawanami, Takafumi Mizuta, Shuichi Fukushima, Toshihiro Mizumaki, Hiroki Yamaguchi, Masaki Masaki, Yasufumi Intern Med Case Report A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis. The Japanese Society of Internal Medicine 2019-06-07 2019-09-01 /pmc/articles/PMC6761330/ /pubmed/31178507 http://dx.doi.org/10.2169/internalmedicine.2738-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Fujimoto, Shino Sakai, Tomoyuki Kawabata, Hiroshi Kurose, Nozomu Yamada, Sohsuke Doai, Mariko Matoba, Munetaka Iwao-Kawanami, Haruka Kawanami, Takafumi Mizuta, Shuichi Fukushima, Toshihiro Mizumaki, Hiroki Yamaguchi, Masaki Masaki, Yasufumi Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease |
title | Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease |
title_full | Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease |
title_fullStr | Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease |
title_full_unstemmed | Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease |
title_short | Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease |
title_sort | osteosarcoma manifesting systemic inflammation and histological features mimicking plasma cell-type castleman disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761330/ https://www.ncbi.nlm.nih.gov/pubmed/31178507 http://dx.doi.org/10.2169/internalmedicine.2738-19 |
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