A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component

The present report describes an extremely rare case of Barrett's adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett's esophagus. The patient underwent endoscopic submucosal dissection, but the patho...

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Autores principales: Takeuchi, Akio, Hatta, Waku, Koike, Tomoyuki, Saito, Masahiro, Jin, Xiaoyi, Asanuma, Kiyotaka, Uno, Kaname, Asano, Naoki, Imatani, Akira, Fujishima, Fumiyoshi, Masamune, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761343/
https://www.ncbi.nlm.nih.gov/pubmed/31118396
http://dx.doi.org/10.2169/internalmedicine.2722-19
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author Takeuchi, Akio
Hatta, Waku
Koike, Tomoyuki
Saito, Masahiro
Jin, Xiaoyi
Asanuma, Kiyotaka
Uno, Kaname
Asano, Naoki
Imatani, Akira
Fujishima, Fumiyoshi
Masamune, Atsushi
author_facet Takeuchi, Akio
Hatta, Waku
Koike, Tomoyuki
Saito, Masahiro
Jin, Xiaoyi
Asanuma, Kiyotaka
Uno, Kaname
Asano, Naoki
Imatani, Akira
Fujishima, Fumiyoshi
Masamune, Atsushi
author_sort Takeuchi, Akio
collection PubMed
description The present report describes an extremely rare case of Barrett's adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett's esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor.
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spelling pubmed-67613432019-09-27 A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component Takeuchi, Akio Hatta, Waku Koike, Tomoyuki Saito, Masahiro Jin, Xiaoyi Asanuma, Kiyotaka Uno, Kaname Asano, Naoki Imatani, Akira Fujishima, Fumiyoshi Masamune, Atsushi Intern Med Case Report The present report describes an extremely rare case of Barrett's adenocarcinoma (BAC) with a squamous cell carcinoma (SCC) component. A 55-year-old man was diagnosed with esophageal adenocarcinoma on Barrett's esophagus. The patient underwent endoscopic submucosal dissection, but the pathology revealed deep submucosal invasive, moderately differentiated tubular adenocarcinoma and focal SCC with vascular invasion. In addition, morphological transition between adenocarcinoma and SCC components was confirmed. The patient underwent additional surgery, which revealed lymph node metastasis, and then received S-1 adjuvant chemotherapy. Based on the pathological findings, the transdifferentiation process may have a role in the histogenesis of this tumor. The Japanese Society of Internal Medicine 2019-05-22 2019-09-01 /pmc/articles/PMC6761343/ /pubmed/31118396 http://dx.doi.org/10.2169/internalmedicine.2722-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takeuchi, Akio
Hatta, Waku
Koike, Tomoyuki
Saito, Masahiro
Jin, Xiaoyi
Asanuma, Kiyotaka
Uno, Kaname
Asano, Naoki
Imatani, Akira
Fujishima, Fumiyoshi
Masamune, Atsushi
A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component
title A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component
title_full A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component
title_fullStr A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component
title_full_unstemmed A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component
title_short A Primary Barrett's Adenocarcinoma with a Squamous Cell Carcinoma Component
title_sort primary barrett's adenocarcinoma with a squamous cell carcinoma component
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761343/
https://www.ncbi.nlm.nih.gov/pubmed/31118396
http://dx.doi.org/10.2169/internalmedicine.2722-19
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