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GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis

G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas are the most common malignant brain cancers in children. GRK2 has not been implicated in medulloblastoma biology. Here we re...

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Detalles Bibliográficos
Autores principales: Pathania, Anup S., Ren, Xiuhai, Mahdi, Min Y., Shackleford, Gregory M., Erdreich-Epstein, Anat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761358/
https://www.ncbi.nlm.nih.gov/pubmed/31554835
http://dx.doi.org/10.1038/s41598-019-50157-5

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