Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury. The mechanism of injury after ICH is very complicated and has not yet bee...

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Detalles Bibliográficos
Autores principales: Shao, Zhiwei, Tu, Sheng, Shao, Anwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761372/
https://www.ncbi.nlm.nih.gov/pubmed/31607923
http://dx.doi.org/10.3389/fphar.2019.01079
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author Shao, Zhiwei
Tu, Sheng
Shao, Anwen
author_facet Shao, Zhiwei
Tu, Sheng
Shao, Anwen
author_sort Shao, Zhiwei
collection PubMed
description Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury. The mechanism of injury after ICH is very complicated and has not yet been illuminated. This review discusses some key pathophysiology mechanisms in ICH such as oxidative stress (OS), inflammation, iron toxicity, and thrombin formation. The corresponding therapeutic targets and therapeutic strategies are also reviewed.
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spelling pubmed-67613722019-10-13 Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage Shao, Zhiwei Tu, Sheng Shao, Anwen Front Pharmacol Pharmacology Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury. The mechanism of injury after ICH is very complicated and has not yet been illuminated. This review discusses some key pathophysiology mechanisms in ICH such as oxidative stress (OS), inflammation, iron toxicity, and thrombin formation. The corresponding therapeutic targets and therapeutic strategies are also reviewed. Frontiers Media S.A. 2019-09-19 /pmc/articles/PMC6761372/ /pubmed/31607923 http://dx.doi.org/10.3389/fphar.2019.01079 Text en Copyright © 2019 Shao, Tu and Shao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shao, Zhiwei
Tu, Sheng
Shao, Anwen
Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
title Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
title_full Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
title_fullStr Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
title_full_unstemmed Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
title_short Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
title_sort pathophysiological mechanisms and potential therapeutic targets in intracerebral hemorrhage
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761372/
https://www.ncbi.nlm.nih.gov/pubmed/31607923
http://dx.doi.org/10.3389/fphar.2019.01079
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