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Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma

The aim of this study is to explore the expression of osteopontin (OPN) and its relationship with prognostic factors and survival in diffuse large B cell lymphoma (DLBCL). A tissue microarray was performed for immunohistochemical evaluation. Contingency tables were analyzed for trends; chi-square te...

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Autores principales: Barranco, Gilberto, Fernández, Edith, Rivas, Silvia, Quezada, Roxana, Nava, Dolores, Aguilar, José, García, Abelardo, Astudillo, Horacio, Lome, Carmen, Ruiz, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761465/
https://www.ncbi.nlm.nih.gov/pubmed/31579151
http://dx.doi.org/10.4081/hr.2019.7964
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author Barranco, Gilberto
Fernández, Edith
Rivas, Silvia
Quezada, Roxana
Nava, Dolores
Aguilar, José
García, Abelardo
Astudillo, Horacio
Lome, Carmen
Ruiz, Erika
author_facet Barranco, Gilberto
Fernández, Edith
Rivas, Silvia
Quezada, Roxana
Nava, Dolores
Aguilar, José
García, Abelardo
Astudillo, Horacio
Lome, Carmen
Ruiz, Erika
author_sort Barranco, Gilberto
collection PubMed
description The aim of this study is to explore the expression of osteopontin (OPN) and its relationship with prognostic factors and survival in diffuse large B cell lymphoma (DLBCL). A tissue microarray was performed for immunohistochemical evaluation. Contingency tables were analyzed for trends; chi-square test was used to determine differences between groups. Univariate and multivariate Cox proportional hazards-regression analyses were performed to evaluate the impact of prognostic factors on survival. Expression of OPN was observed in 28%. It was different in non-germinal center DLBCL (P=0.04). The mean overall survival (OS) was lower in patients with positive OPN expression (19.762; CI 95% 14.269-25.255) it was not significant (P=0.123). It is not possible to establish a clear relationship between the expression by immunohistochemistry of osteopontin and a poor prognosis but it would be important to complement the analysis with other techniques as PCR or NGS that allow us to assess the influence of the isoforms and post-translational modifications of OPN on the biological behavior of DLBCL. Our findings indicate that OPN expression could be associated with a more aggressive variant of lymphoma: non-germinal center DLBCL.
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spelling pubmed-67614652019-10-02 Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma Barranco, Gilberto Fernández, Edith Rivas, Silvia Quezada, Roxana Nava, Dolores Aguilar, José García, Abelardo Astudillo, Horacio Lome, Carmen Ruiz, Erika Hematol Rep Article The aim of this study is to explore the expression of osteopontin (OPN) and its relationship with prognostic factors and survival in diffuse large B cell lymphoma (DLBCL). A tissue microarray was performed for immunohistochemical evaluation. Contingency tables were analyzed for trends; chi-square test was used to determine differences between groups. Univariate and multivariate Cox proportional hazards-regression analyses were performed to evaluate the impact of prognostic factors on survival. Expression of OPN was observed in 28%. It was different in non-germinal center DLBCL (P=0.04). The mean overall survival (OS) was lower in patients with positive OPN expression (19.762; CI 95% 14.269-25.255) it was not significant (P=0.123). It is not possible to establish a clear relationship between the expression by immunohistochemistry of osteopontin and a poor prognosis but it would be important to complement the analysis with other techniques as PCR or NGS that allow us to assess the influence of the isoforms and post-translational modifications of OPN on the biological behavior of DLBCL. Our findings indicate that OPN expression could be associated with a more aggressive variant of lymphoma: non-germinal center DLBCL. PAGEPress Publications, Pavia, Italy 2019-09-18 /pmc/articles/PMC6761465/ /pubmed/31579151 http://dx.doi.org/10.4081/hr.2019.7964 Text en ©Copyright: the Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Barranco, Gilberto
Fernández, Edith
Rivas, Silvia
Quezada, Roxana
Nava, Dolores
Aguilar, José
García, Abelardo
Astudillo, Horacio
Lome, Carmen
Ruiz, Erika
Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma
title Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma
title_full Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma
title_fullStr Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma
title_full_unstemmed Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma
title_short Osteopontin expression and its relationship with prognostic factors in diffuse large B-cell lymphoma
title_sort osteopontin expression and its relationship with prognostic factors in diffuse large b-cell lymphoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761465/
https://www.ncbi.nlm.nih.gov/pubmed/31579151
http://dx.doi.org/10.4081/hr.2019.7964
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