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Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)

BACKGROUND: Shift work has well-known adverse effects on health. However, few studies have investigated the relationship between shift work and hepatic disorders. This study aimed to evaluate the association between shift work and abnormal level of liver enzymes. METHODS: The aggregated data from th...

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Autores principales: Choi, Hyeongyeong, Oh, Hyun-Jeong, Shin, Ji-Su, Lim, MyeongSeob, Kim, Sung-Kyung, Kang, Hee-Tae, Oh, Sung-Soo, Koh, Sang-Baek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Occupational & Environmental Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761479/
https://www.ncbi.nlm.nih.gov/pubmed/31583106
http://dx.doi.org/10.35371/aoem.2019.31.e15
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author Choi, Hyeongyeong
Oh, Hyun-Jeong
Shin, Ji-Su
Lim, MyeongSeob
Kim, Sung-Kyung
Kang, Hee-Tae
Oh, Sung-Soo
Koh, Sang-Baek
author_facet Choi, Hyeongyeong
Oh, Hyun-Jeong
Shin, Ji-Su
Lim, MyeongSeob
Kim, Sung-Kyung
Kang, Hee-Tae
Oh, Sung-Soo
Koh, Sang-Baek
author_sort Choi, Hyeongyeong
collection PubMed
description BACKGROUND: Shift work has well-known adverse effects on health. However, few studies have investigated the relationship between shift work and hepatic disorders. This study aimed to evaluate the association between shift work and abnormal level of liver enzymes. METHODS: The aggregated data from the 2007–2009, 2010–2012, and 2013–2015 cycles of the Korea National Health and Nutrition Examination Survey was used for this study. The χ(2) test and multiple logistic regression analysis were used to assess relationship between shift work and abnormal level of liver enzymes stratified by gender. RESULTS: The odds ratio (OR) of abnormal serum level of alanine aminotransferase (abnormal ALT) in female shift workers was higher with 1.31 (95% confidence interval: 1.00–1.71) compared with day workers after adjusting for covariates. After dividing into subgroups of the shift work pattern, the ORs of abnormal liver enzymes for each pattern compared with day work were not significantly higher. CONCLUSIONS: This study provides limited support for the hypothesis that shift work is related to liver enzyme abnormalities, but offers some evidence in favor of the idea that shift work affects female workers more than males on abnormal ALT. Further studies are needed to define the relationship between shift work and abnormal liver enzymes to be carried out as well as the gender difference in the association.
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spelling pubmed-67614792019-10-03 Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015) Choi, Hyeongyeong Oh, Hyun-Jeong Shin, Ji-Su Lim, MyeongSeob Kim, Sung-Kyung Kang, Hee-Tae Oh, Sung-Soo Koh, Sang-Baek Ann Occup Environ Med Research Article BACKGROUND: Shift work has well-known adverse effects on health. However, few studies have investigated the relationship between shift work and hepatic disorders. This study aimed to evaluate the association between shift work and abnormal level of liver enzymes. METHODS: The aggregated data from the 2007–2009, 2010–2012, and 2013–2015 cycles of the Korea National Health and Nutrition Examination Survey was used for this study. The χ(2) test and multiple logistic regression analysis were used to assess relationship between shift work and abnormal level of liver enzymes stratified by gender. RESULTS: The odds ratio (OR) of abnormal serum level of alanine aminotransferase (abnormal ALT) in female shift workers was higher with 1.31 (95% confidence interval: 1.00–1.71) compared with day workers after adjusting for covariates. After dividing into subgroups of the shift work pattern, the ORs of abnormal liver enzymes for each pattern compared with day work were not significantly higher. CONCLUSIONS: This study provides limited support for the hypothesis that shift work is related to liver enzyme abnormalities, but offers some evidence in favor of the idea that shift work affects female workers more than males on abnormal ALT. Further studies are needed to define the relationship between shift work and abnormal liver enzymes to be carried out as well as the gender difference in the association. Korean Society of Occupational & Environmental Medicine 2019-07-31 /pmc/articles/PMC6761479/ /pubmed/31583106 http://dx.doi.org/10.35371/aoem.2019.31.e15 Text en Copyright © 2019 Korean Society of Occupational & Environmental Medicine https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Choi, Hyeongyeong
Oh, Hyun-Jeong
Shin, Ji-Su
Lim, MyeongSeob
Kim, Sung-Kyung
Kang, Hee-Tae
Oh, Sung-Soo
Koh, Sang-Baek
Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)
title Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)
title_full Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)
title_fullStr Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)
title_full_unstemmed Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)
title_short Relationship between shift work and liver enzymes: a cross-sectional study based on the Korea National Health and Examination Survey (2007–2015)
title_sort relationship between shift work and liver enzymes: a cross-sectional study based on the korea national health and examination survey (2007–2015)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761479/
https://www.ncbi.nlm.nih.gov/pubmed/31583106
http://dx.doi.org/10.35371/aoem.2019.31.e15
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