Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus

We evaluated extended-interval dosing of the investigational echinocandin rezafungin (1, 4, and 16 mg/kg on days 1, 4, and 7 postinoculation) for the treatment of disseminated invasive aspergillosis caused by azole-resistant Aspergillus fumigatus. Survival was significantly improved in mice treated...

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Autores principales: Wiederhold, Nathan P., Najvar, Laura K., Jaramillo, Rosie, Olivo, Marcos, Wickes, Brian L., Catano, Gabriel, Patterson, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761546/
https://www.ncbi.nlm.nih.gov/pubmed/31405851
http://dx.doi.org/10.1128/AAC.01165-19
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author Wiederhold, Nathan P.
Najvar, Laura K.
Jaramillo, Rosie
Olivo, Marcos
Wickes, Brian L.
Catano, Gabriel
Patterson, Thomas F.
author_facet Wiederhold, Nathan P.
Najvar, Laura K.
Jaramillo, Rosie
Olivo, Marcos
Wickes, Brian L.
Catano, Gabriel
Patterson, Thomas F.
author_sort Wiederhold, Nathan P.
collection PubMed
description We evaluated extended-interval dosing of the investigational echinocandin rezafungin (1, 4, and 16 mg/kg on days 1, 4, and 7 postinoculation) for the treatment of disseminated invasive aspergillosis caused by azole-resistant Aspergillus fumigatus. Survival was significantly improved in mice treated with each dose of rezafungin and supratherapeutic posaconazole (20 mg/kg twice daily). Kidney fungal burden, as measured by quantitative real-time PCR, was also significantly reduced in mice treated with rezafungin although variability was observed.
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spelling pubmed-67615462019-10-01 Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus Wiederhold, Nathan P. Najvar, Laura K. Jaramillo, Rosie Olivo, Marcos Wickes, Brian L. Catano, Gabriel Patterson, Thomas F. Antimicrob Agents Chemother Experimental Therapeutics We evaluated extended-interval dosing of the investigational echinocandin rezafungin (1, 4, and 16 mg/kg on days 1, 4, and 7 postinoculation) for the treatment of disseminated invasive aspergillosis caused by azole-resistant Aspergillus fumigatus. Survival was significantly improved in mice treated with each dose of rezafungin and supratherapeutic posaconazole (20 mg/kg twice daily). Kidney fungal burden, as measured by quantitative real-time PCR, was also significantly reduced in mice treated with rezafungin although variability was observed. American Society for Microbiology 2019-09-23 /pmc/articles/PMC6761546/ /pubmed/31405851 http://dx.doi.org/10.1128/AAC.01165-19 Text en Copyright © 2019 Wiederhold et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Experimental Therapeutics
Wiederhold, Nathan P.
Najvar, Laura K.
Jaramillo, Rosie
Olivo, Marcos
Wickes, Brian L.
Catano, Gabriel
Patterson, Thomas F.
Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
title Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
title_full Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
title_fullStr Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
title_full_unstemmed Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
title_short Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus
title_sort extended-interval dosing of rezafungin against azole-resistant aspergillus fumigatus
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761546/
https://www.ncbi.nlm.nih.gov/pubmed/31405851
http://dx.doi.org/10.1128/AAC.01165-19
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