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p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions

The p53 tumor suppressor regulates distinct responses to cellular stresses. Although different stresses generate different p53 dynamics, the mechanisms by which cells decode p53 dynamics to differentially regulate target genes are not well understood. Here, we determined in individual cells how cano...

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Detalles Bibliográficos
Autores principales: Harton, Marie D, Koh, Woo Seuk, Bunker, Amie D, Singh, Abhyudai, Batchelor, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761572/
https://www.ncbi.nlm.nih.gov/pubmed/31556489
http://dx.doi.org/10.15252/msb.20188685