Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for...

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Detalles Bibliográficos
Autores principales: Roberts, David J, Davis, Grahame S, Cole, Michelle J, Naik, Dixita, Maru, Hitiksha, Woodford, Neil, Muir, Peter, Horner, Paddy, Simms, Ian, Thickett, George, Crook, Paul, Foster, Kirsty, Andrews, Nick, Saunders, John, Fifer, Helen, Folkard, Kate, Gill, O Noel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761577/
https://www.ncbi.nlm.nih.gov/pubmed/31552817
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.38.1900557
Descripción
Sumario:We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

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