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Phosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts

BACKGROUND: In murine heart failure models and in humans with diabetic‐related heart hypertrophy, inhibition of phosphodiesterase 5 (PDE5) by sildenafil improves cardiac outcomes. However, the mechanism by which sildenafil improves cardiac function is unclear. We have observed a relationship between...

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Detalles Bibliográficos
Autores principales:	West, Toni M., Wang, Qingtong, Deng, Bingqing, Zhang, Yu, Barbagallo, Federica, Reddy, Gopireddy R., Chen, Dana, Phan, Kyle S., Xu, Bing, Isidori, Andres, Xiang, Yang K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761630/ https://www.ncbi.nlm.nih.gov/pubmed/31311394 http://dx.doi.org/10.1161/JAHA.119.012273

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