Cargando…

Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy

BACKGROUND: In mammals, muscle contraction is controlled by a family of 10 sarcomeric myosin motors. The expression of one of its members, MYH7b, is regulated by alternative splicing, and while the protein is restricted to specialized muscles such as extraocular muscles or muscle spindles, RNA that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peter, Angela K., Rossi, Alberto C., Buvoli, Massimo, Ozeroff, Christopher D., Crocini, Claudia, Perry, Amy R., Buvoli, Ada E., Lee, Lindsey A., Leinwand, Leslie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761648/ https://www.ncbi.nlm.nih.gov/pubmed/31364453 http://dx.doi.org/10.1161/JAHA.119.013318

Ejemplares similares

Interplay between Exonic Splicing Enhancers, mRNA Processing, and mRNA Surveillance in the Dystrophic Mdx Mouse
por: Buvoli, Massimo, et al.
Publicado: (2007)

Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart
por: Lee, Lindsey A., et al.
Publicado: (2021)

Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b
por: Lee, Lindsey A., et al.
Publicado: (2023)

Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture
por: Feinstein-Linial, Miora, et al.
Publicado: (2016)

Skeletal myosin heavy chain function in cultured lung myofibroblasts
por: Rice, Nancy A., et al.
Publicado: (2003)

miR-1/206 downregulates splicing factor Srsf9 to promote C2C12 differentiation
por: Bjorkman, Kristen K., et al.
Publicado: (2019)

Myosin Heavy Chains IIa and IId Are Functionally Distinct in the Mouse
por: Sartorius, Carol A., et al.
Publicado: (1998)

IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men
por: Harrison, Brooke C, et al.
Publicado: (2011)

Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies
por: Lehman, Sarah J., et al.
Publicado: (2023)

Dilated Cardiomyopathy Mutation (R134W) in Mouse Cardiac Troponin T Induces Greater Contractile Deficits against α-Myosin Heavy Chain than against β-Myosin Heavy Chain
por: Gollapudi, Sampath K., et al.
Publicado: (2016)

Growth and Muscle Defects in Mice Lacking Adult Myosin Heavy Chain Genes
por: Acakpo-Satchivi, Leslie J.R., et al.
Publicado: (1997)

Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy
por: Hodatsu, Akihiko, et al.
Publicado: (2019)

The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β-Myosin
por: Bloemink, Marieke, et al.
Publicado: (2014)

The ancient sarcomeric myosins found in specialized muscles
por: Lee, Lindsey A., et al.
Publicado: (2019)

The expression of myosin heavy chain isoforms in normal and hypertrophied chicken slow muscle
Publicado: (1986)

Developmental, physiologic and phylogenetic perspectives on the expression and regulation of myosin heavy chains in mammalian skeletal muscles
por: Hoh, Joseph Foon Yoong
Publicado: (2023)

Unexpectedly Low Mutation Rates in Beta-Myosin Heavy Chain and Cardiac Myosin Binding Protein Genes in Italian Patients With Hypertrophic Cardiomyopathy
por: Roncarati, Roberta, et al.
Publicado: (2011)

Developmental myosins: expression patterns and functional significance
por: Schiaffino, Stefano, et al.
Publicado: (2015)

Identification of a new mechanism for targeting myosin II heavy chain phosphorylation by Dictyostelium myosin heavy chain kinase B
por: Underwood, Julie, et al.
Publicado: (2010)

Synthesis of myosin heavy and light chains in muscle cultures
Publicado: (1975)

Caenorhabditis elegans Unc-45 Is a Component of Muscle Thick Filaments and Colocalizes with Myosin Heavy Chain B, but Not Myosin Heavy Chain a
por: Ao, Wanyuan, et al.
Publicado: (2000)

Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy
por: Hsieh, Jeanne, et al.
Publicado: (2022)

Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development
Publicado: (1996)

An unconventional myosin heavy chain gene from Drosophila melanogaster
Publicado: (1992)

Transient ventricular fibrillation and myosin heavy chain isoform profile
por: Manoach, M, et al.
Publicado: (2007)

Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?
por: Wang, Yunmei, et al.
Publicado: (2019)

Cellular mechanisms of cardiomyopathy
por: Harvey, Pamela A., et al.
Publicado: (2011)

Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis
por: Feng, Zhonghui, et al.
Publicado: (2015)

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice
por: Yuan, Chen-Ching, et al.
Publicado: (2018)

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes
por: Alamo, Lorenzo, et al.
Publicado: (2017)

Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α‐ and β‐Myosin Heavy Chain Isoforms
por: Michael, John Jeshurun, et al.
Publicado: (2016)

Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemomechanical properties despite bearing the same myosin heavy chain isoform
por: Wang, Tianbang, et al.
Publicado: (2022)

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin
por: Rasicci, David V, et al.
Publicado: (2022)

Effect of heavy chain phosphorylation on the polymerization and structure of Dictyostelium myosin filaments
Publicado: (1987)

Redox Regulation of Nonmuscle Myosin Heavy Chain during Integrin Engagement
por: Fiaschi, Tania, et al.
Publicado: (2012)

Differential isoform expression of SERCA and myosin heavy chain in hypopharyngeal muscles
por: ELRABIE AHMED, MOHAMMED, et al.
Publicado: (2019)

Aurora-B phosphorylates the myosin II heavy chain to promote cytokinesis
por: Babkoff, Aryeh, et al.
Publicado: (2021)

Myosin Heavy Chain 9 (MYH9)-Related Congenital Macrothrombocytopenia
por: Thurlapati, Aswani, et al.
Publicado: (2021)

Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis
por: Takahashi, Lisa, et al.
Publicado: (2021)

The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development
por: Yahya, Imadeldin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3e4dgupgsg0frh8l0ehno1sbsj