Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease

BACKGROUND: Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase. BH4 availability is reduced upon NOS activation, such as...

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Detalles Bibliográficos
Autores principales: Romanowicz, Jennifer, Leonetti, Camille, Dhari, Zaenab, Korotcova, Ludmila, Ramachandra, Shruti D., Saric, Nemanja, Morton, Paul D., Bansal, Shivani, Cheema, Amrita, Gallo, Vittorio, Jonas, Richard A., Ishibashi, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761654/
https://www.ncbi.nlm.nih.gov/pubmed/31331224
http://dx.doi.org/10.1161/JAHA.119.012711

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